DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7381 and pqn-25

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_741140.1	Gene:	pqn-25 / 175759	WormBaseID:	WBGene00004114	Length:	672	Species:	Caenorhabditis elegans

Alignment Length:	750	Identity:	156/750 - (20%)
Similarity:	259/750 - (34%)	Gaps:	216/750 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 WFLTLGVLCCAVLSPQGDGGVLAVF----------------WPCETEADCTADGTSCDFASGQ-- 52
            :||.|.:...:|:| |...|:..:|                ..|.:.:..:..||.|.:||..
Worm    35 FFLLLQIFVISVVS-QCPPGLTPLFSNSNFNQPLTCTPQDACSCYSSSGSSRFGTICQYASTYNN 98

  Fly    53 --CECSTFDTVLAENFTQCLATSLIGEKCDDSVQCNLMPTGASCKAGVC---------------D 100
              | |.:.:|....|.:..::.|.....|..:.||   .:|.:|..|.|               .
Worm    99 YIC-CYSTNTQCGSNSSPQVSASGQVVTCSTNTQC---ASGYTCNNGACCPNTNSNTCSSNGNNG 159

  Fly   101 CADGQNYLRGKCRPLNGLGESCETDLDCYFGYDRASVSCQQNVCGCANGYYNRYGNICRRKSMEE 165
            |..||..:.|:|.....:|.:|::...|..|     ..||.|:|.|.:||.|            .
Worm   160 CLAGQTMVNGQCYNSVNIGSACQSTQQCLGG-----SQCQNNICQCYSGYVN------------V 207

  Fly   166 NDACVVNADCDELGAGVEC-VGLVCTYVDEITTTPGGETEETETTNPGSPEDDDSTTAEAITETA 229
            |..||::       .|:.| :|.| :|..:..|.             .||..:..|:::.|..:.
Worm   208 NQQCVIS-------NGLNCQLGTV-SYNSQCITL-------------ASPGQNCQTSSQCIDNSV 251

  Fly   230 DPEQETAFSSRRQLTKAFVHAPPPTHSDAAAQVSFAQLTNGDTEPLISPRSHEIAV--QTSIEKY 292
            ...|....::..:|...:.   .|..|....|          |:.|::.:...:::  :|.|...
Worm   252 CMNQMCTCNNNYRLVYGYC---VPITSSICQQ----------TQTLVNNQCVLLSIVGETCIANQ 303

  Fly   293 ELREVGRSVRNAATATTTTTATAS-----TSTSSRRNSSRNQRHAHGQRRRLPALFRFDDEDIKT 352
            :.  ||.::.|:.|...|..|||.     :|:||..||  ||...:|.                .
Worm   304 QC--VGGAMCNSGTCQCTNGATAMYGYCISSSSSSCNS--NQVSINGM----------------C 348

  Fly   353 YSTLGSSRDDDDADEKKYGSSCTDNGKTCSGLPHSICSKNICL-------CRQGYYARNGKC--F 408
            |:|:            :.|.||:.: :.|  |.:::|:.|||:       |.......:.:|  :
Worm   349 YNTV------------QVGGSCSFS-QQC--LNNAVCTNNICVSTFCSVSCSTNQVCISNQCYNY 398

  Fly   409 AELGEIAESTDECEYEFDQLTKTCNCQKNYFYERDLRNCRKPIQYHLSCT----SNSQCSPFGAS 469
            ..:|.....:.:|......::..|.|.:.            ..|.:..||    :|:||.|...
Worm   399 VSIGSQCVGSQQCLSNSQCISSICQCPQG------------TQQSNGVCTGNNNNNNQCQPNQV- 450

  Fly   470 YCHPEIPRRCTCEEYALYDAIKQLCEYKRGLGAECESNDGCPVDHSVCSNRVCVCADNYFEKDDQ 534
                               .|...|.....:|.:|:....| :.:|.|.|.:|.|.......:..
Worm   451 -------------------LINNQCYNTVSIGFQCQFPQQC-LGNSQCMNSMCQCPTGSTNVNGY 495

  Fly   535 CMRGIGADCSVEDDCIPENTECQEKDEEDQSRTCQCRKGYVHFKDECLKEAEELEDECVEDEQCK 599
            |..|....|:.....|  |.:|.    ...|...||:     |..:||..::.|...|    ||.
Worm   496 CQGGSNGQCNSNQVLI--NNQCY----NTVSIGFQCQ-----FAQQCLGNSQCLNSIC----QCP 545

  Fly   600 PLLASCNSEGKC------GCNDEQHAKNGVCETKRELGESCTKATECYVEKDPENVECRNSVCQC 658
            .  .|.|..|.|      .||..|...|..|.....:|..|....:|.     .|.:|.||.|||
Worm   546 S--GSSNVNGYCQGGSNGQCNSNQVYYNNQCYNTVPIGSQCQITQQCL-----GNSQCMNSFCQC 603

  Fly   659 KLG--------YSANANQNQCIRVMPNKKNSSGRP 685
            ..|        .:::::.|.|......:.:||.:|
Worm   604 PSGTTNVNNFCTTSSSSSNLCSAGQTVQLDSSNQP 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949	12/58 (21%)
		EB	101..155	CDD:279949	17/53 (32%)
		EB	570..624	CDD:279949	16/59 (27%)
		EB	613..665	CDD:279949	16/59 (27%)
pqn-25	NP_741140.1	EB	160..211	CDD:279949	18/67 (27%)
		EB	219..270	CDD:279949	11/64 (17%)
		EB	278..329	CDD:279949	13/62 (21%)
		EB	341..>376	CDD:279949	12/65 (18%)
		EB	384..435	CDD:279949	7/62 (11%)
		EB	450..496	CDD:279949	10/66 (15%)
		EB	504..555	CDD:279949	17/67 (25%)
		EB	563..614	CDD:279949	16/55 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I3746
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28671
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.870