DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7381 and Dkk3

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_612528.2	Gene:	Dkk3 / 171548	RGDID:	621846	Length:	348	Species:	Rattus norvegicus

Alignment Length:	317	Identity:	60/317 - (18%)
Similarity:	99/317 - (31%)	Gaps:	102/317 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 DTEPLISPRSHEIAVQTSIEKYELREVGRSVRNAATATTTTTATAST-------STSSRRNSSRN 328
            :.|.|:....|::  ::::|:.|..|        |.|.|::..|.|:       .|::......|
  Rat    53 EVEELMEDTQHKL--RSAVEEMEAEE--------AAARTSSEVTLSSLPANYHNETNTETRMENN 107

  Fly   329 QRHAHGQRRRL------PALFR-------FDDEDIKTYSTLGSSRDDDDADEKKY---------G 371
            ..|.|.:..::      ..:|.       .|.|..|::..:    .|:|....:|         .
  Rat   108 TAHVHREVHKITNNQSGQTVFSETVITSVEDGEGKKSHECI----IDEDCGPTRYCQFSSFKYTC 168

  Fly   372 SSCTDNGKTCSGLPHSICSKNICL---CRQGYYARNGKCFAELGEIAESTDECEYEFDQLTKTCN 433
            ..|.|....|: .....|...:|.   |.|  .|..|    ..|.|.::..:|     |....|.
  Rat   169 QPCRDQQMLCT-RDSECCGDQLCAWGHCTQ--KATKG----SNGTICDNQRDC-----QPGLCCA 221

  Fly   434 CQKNYFY--------ERDLRNCRKPIQYHLS----------------CTSNSQCSPFGAS---YC 471
            .|:...:        |.:|  |..|....|.                |.|...|.|...|   .|
  Rat   222 FQRGLLFPVCTPLPVEGEL--CHDPTSQMLDLITWELEPEGALDRCPCASGLLCQPHSHSLVYMC 284

  Fly   472 HP------------EIPRRC--TCEEYALYDAIKQ-LCEYKRGLGAECESNDGCPVD 513
            .|            ::||..  ..|:......::| |.:.:|.|..|....:..|||
  Rat   285 KPAFVGSHDHNEESQLPREALDDYEDVGFIGEVRQELEDLERSLAQEMAFEEATPVD 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949
		EB	101..155	CDD:279949
		EB	570..624	CDD:279949
		EB	613..665	CDD:279949
Dkk3	NP_612528.2	Dickkopf_N	147..196	CDD:282549	8/53 (15%)
Dkk3	NP_612528.2	Prokineticin	<208..273	CDD:148298	11/71 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900