DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7381 and AgaP_AGAP001638

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	XP_321457.5	Gene:	AgaP_AGAP001638 / 1281533	VectorBaseID:	AGAP001638	Length:	689	Species:	Anopheles gambiae

Alignment Length:	783	Identity:	249/783 - (31%)
Similarity:	356/783 - (45%)	Gaps:	183/783 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QWFLTLGVLCCAVLS-PQGDG------------------GVLAVFWPCETEADCTADGTSCDFAS 50
            |::.|:.:|..|::| |....                  |..::.||||..:||.|:...|.. .
Mosquito    14 QFWKTIQLLLAALISFPNSHSFTTTKPFFLSLSPSPTITGSRSIIWPCEDSSDCKAENAHCSI-Y 77

  Fly    51 GQCECSTFDTVLAENFTQCLATSLIGEKCDDSVQCNLMPTGASCKAGVCDCADGQNYLRGKCRPL 115
            |.|:|.. ..|.:.:.|:||..|..|..|.::|||:.|.|||.|:||||.|.....|:||:||.|
Mosquito    78 GYCQCPA-GYVFSTDVTRCLPESAYGVACQEAVQCSHMLTGAKCEAGVCTCDSDYTYVRGRCRKL 141

  Fly   116 NGLGESCETDLDCYFGYDRASVSCQQNVCGCANGYYNRYGNICRRK------------------- 161
            ..||:.|..|:||:|.::|.||.|.:..|.||:|:|.|..|:|||:
Mosquito   142 VDLGQPCSDDIDCFFSHNRESVVCHRGSCECADGFYRRSSNVCRRRVTKKLLKSRVSSMFGLKYK 206

  Fly   162 ----------------SMEENDACVVNADCDELGAGVECVGLVCTYVDEITTTPGGETEETETTN 210
                            |..:.:.|:|:.|||  |..:.||...||
Mosquito   207 NRSLSIKPSILYLFKPSPTDGEECLVHQDCD--GDNLRCVNQRCT-------------------- 249

  Fly   211 PGSPEDDDSTTAEAITETADPEQETAFSSRRQLTKAFVH-----APPPTHSDAAAQVSFAQLTNG 270
                        :|..:||...|:.|..:.:.|.|..|.     |||
Mosquito   250 ------------DAAAQTAKSLQDVAIQTSQSLEKPHVEGSPAKAPP------------------ 284

  Fly   271 DTEPLISPRSHEIAVQTSIEKYELREVGRSVRNAATATTTTTATASTSTSSRRNSSRNQRHAHGQ 335
                  :|::                     |:|.|.|.|..||
Mosquito   285 ------APKT---------------------RDAETNTDTAAAT--------------------- 301

  Fly   336 RRRLPALFRFDDEDIKTYSTLGSSRDDDDADEKKYGSSCTDNGKTCSGLPHSICSKNICLCRQGY 400
             :|:..::...|.::..:   ||.....:......|..|.:.|..|..:|:::|....|.||:||
Mosquito   302 -KRMSQMYGTGDLEVWGF---GSFFYVPELSTFAVGDPCVEEGVECPEVPYTVCRMGQCHCREGY 362

  Fly   401 YARNGKCFAELGEIAESTDECEYEFDQLTKTCNCQKNYFYERDLRNCRK-PIQYHLSCTSNSQCS 464
            |.:.|:|.|||||.......||.......:.|.|:.:.||:.::|.|.| .:..:.|||..||||
Mosquito   363 YHKEGRCMAELGEYVHDGQYCEPGTQFSNRRCTCRNDQFYDNNMRTCLKSALGINTSCTQQSQCS 427

  Fly   465 PFGASYCHPEIPRRCTCEEYALYDAIKQLCEYKRGLGAECESNDGCPVDHSVCS-NRVCVCADNY 528
            |:||:||....|:||||..||.||...:||..|.|..|.||.:..|.:.::.|| .:.|||..:|
Mosquito   428 PYGAAYCPSVSPKRCTCHPYARYDEATELCVAKDGYEAYCERDGDCALANARCSTEKTCVCKPSY 492

  Fly   529 FEKDDQCMRGIGADCSVEDDCIPENTECQEK--DEEDQS------RTCQCRKG--YVHFKDECLK 583
            :..:::|....|.:|....||..|...||..  ..||:|      :.|.|.||  |....:.|||
Mosquito   493 YYVNERCKAANGGECETAADCAFEEAVCQSPSVQSEDESVEPAEPKRCSCGKGHYYQASGNRCLK 557

  Fly   584 EAEELEDECVEDEQCKPLLASCNS--EGKCGCND-EQHAKNGVCETKRELGESCTKATECYVE-K 644
            |||:..|||..||||:|||.....  ||:|.|:: |.|.|:|.|..|..|...|:|.:||:|: .
Mosquito   558 EAEQYGDECSVDEQCQPLLGELGQCIEGQCQCDENEHHFKDGKCNMKIALDARCSKTSECFVDGD 622

  Fly   645 DPENVECRNSVCQCKLGYSANANQNQCIRVMPNKKNSSGRPSALKIITFMLIGSAFLITSAAIKQ 709
            |.:|||||||.||||..||.:..:.:|||  |:.||||.||||||:||.:|..:|.|||.:|::.
Mosquito   623 DQDNVECRNSACQCKFDYSPDVERQKCIR--PSGKNSSDRPSALKVITLLLTSAAVLITGSALRD 685

  Fly   710 AYY 712
            |||
Mosquito   686 AYY 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949	21/43 (49%)
		EB	101..155	CDD:279949	24/53 (45%)
		EB	570..624	CDD:279949	28/58 (48%)
		EB	613..665	CDD:279949	27/53 (51%)
AgaP_AGAP001638	XP_321457.5	EB	82..138	CDD:279949	24/56 (43%)
		EB	127..184	CDD:279949	25/56 (45%)
		EB	547..601	CDD:279949	25/53 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	70	1.000	Domainoid score	I16533
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15123
Inparanoid	1	1.050	312	1.000	Inparanoid score	I4930
OMA	1	1.010	-	-		QHG28671
OrthoDB	1	1.010	-	-		D561378at2759
OrthoFinder	1	1.000	-	-		FOG0019711
OrthoInspector	1	1.000	-	-		oto110015
Panther	1	1.100	-	-	LDO	PTHR39069
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X15255
TreeFam	0	0.000	Not matched by this tool.
	11	11.080