DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7381 and megf11

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	XP_002938407.3	Gene:	megf11 / 100490321	XenbaseID:	XB-GENE-6045392	Length:	1053	Species:	Xenopus tropicalis

Alignment Length:	774	Identity:	170/774 - (21%)
Similarity:	238/774 - (30%)	Gaps:	219/774 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 CAVLSPQGDGGVLAVFWPCETEADCTADGTSCDFASGQCECST--FDTVLAENFTQCLATSLIGE 77
            |..|.|.|..|.|     ||....| .:|..|...:|.|.|..  ..||.|    |...:...|.
Frog   221 CEELCPPGSHGAL-----CELRCPC-QNGGVCHHVTGDCSCPAGWTGTVCA----QPCPSGRFGV 275

  Fly    78 KCDDSVQCNLMPTGASCK--AGVCDCADGQNYLRGKCR---PLNGLGESCETDLDCYFGYDRASV 137
            .|....||:   .|..|.  :|.|.||.|  |...:|:   |:...|..|....||..|     .
Frog   276 NCSQECQCH---NGGQCDPLSGRCQCAAG--YTGERCQEECPVGTYGFQCAERCDCQNG-----A 330

  Fly   138 SCQ--QNVCGCANGYYNRYGNICRRKSMEE-------NDACVVN----ADCDELGAGVEC----V 185
            .|.  ...|.|..|:   .|.:|..:...|       |..|..|    ..|..|.....|    .
Frog   331 KCYHINGACLCEPGF---KGILCEERVCPEGLYGLKCNKNCPCNLTNTRGCHPLSGECTCRAGWS 392

  Fly   186 GLVCTYVDEITTTPG--GE-TEETETTNPGSPEDDDSTTAEAITETADPEQETAFSSRRQLTKAF 247
            ||.|    |....||  || .::..:.:.|:  |.||.|...|.......|:.:
Frog   393 GLYC----EEPCRPGFYGEGCQQLCSCHNGA--DCDSMTGRCICAPGYTGQDCS----------- 440

  Fly   248 VHAPPPTHSDAAAQVSFAQLTNGDTEPLISP-----------RSHEIAVQTSIEKYEL--REVGR 299
              ||..|.:..|..:|   :.|...:...||           :..:.::..|...:.|  .:...
Frog   441 --APCATGTFGADCLS---VCNCQNDAACSPVDGLCVCREGWQGLDCSIPCSSGTWGLNCNQSCL 500

  Fly   300 SVRNAATATTTTTATASTSTSSRRNSSRNQRHAHGQRRRLPALFRFDDEDIKTYSTLGSSRDDDD 364
            .:.:|:.:....:.|.:....             |:....|.|                    |.
Frog   501 CLNDASCSPMDGSCTCAPGWI-------------GELCDQPCL--------------------DG 532

  Fly   365 ADEKKYGSSC--------TDNGKTCSGLPHSI-------CSKNICLCRQGYYARNGK--CFAELG 412
            |    ||..|        .|.....||..|.:       |..   ||.|||:..|..  |..|.|
Frog   533 A----YGMDCLEHCDCSHADGCNPVSGHCHCLAGWTGIHCDN---LCNQGYWGPNCSMTCHCENG 590

  Fly   413 EIAESTDECEYEFDQLTKTCNCQKNYFYERDLRNCRKPIQYHLSCTSNSQCSPFGASYCHPEIPR 477
            ......|          .:|.|...|......|.|......|....:..||..|... || .:..
Frog   591 GSCSPED----------GSCECAPGYRGALCQRICAAGFYGHQCSQTCPQCVHFSGP-CH-HVTG 643

  Fly   478 RCTCEEYALYDAIKQLCEYKR-GLG----AECESNDGC-PVDHSVCSNRVCVCADNYFEKD--DQ 534
            .|.|..........|:|...| |.|    ..|.:|..| |||.|      |.|...:...|  |:
Frog   644 HCDCLPGFFGPLCNQVCPSGRFGKGCAEICSCSNNATCNPVDGS------CQCYPGWIGIDCSDE 702

  Fly   535 CMRGI-GADCSVEDDCIPENTECQEKDEEDQSRTCQCRKGY-----------VHFKDECLKEAEE 587
            |..|: |.|||...:|..| .||...|.|     |:|..|:           ..:..:|....
Frog   703 CPFGLWGPDCSHTCNCHNE-AECSAYDGE-----CKCTPGWTGLYCTQRCPSAFYGKDCANVC-- 759

  Fly   588 LEDECVEDEQCKPLLASCNSE-GKCGCNDEQHAKNGVCETKRELGESCTKATECYVEKDPENVEC 651
               :|.....|..:...|... |..|.:.||....|.      .|..|.:..||.     .|..|
Frog   760 ---QCHNGADCDHITGQCTCRTGFTGNHCEQKCPPGT------FGYGCRQLCECL-----NNATC 810

  Fly   652 RN--SVCQCKLGYSA-NANQ--------NQCIRVMP---NKKNSSGRPSALKIITFMLI 696
            .:  ..|.|..|:.. ..:|        |...::.|   ::::|:|  :.:.:|..:||
Frog   811 DHVTGTCYCNPGFKGIRCDQAALMMEELNPYTKISPAHGSERHSAG--AIIGVIVLLLI 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949	13/45 (29%)
		EB	101..155	CDD:279949	15/58 (26%)
		EB	570..624	CDD:279949	11/65 (17%)
		EB	613..665	CDD:279949	12/54 (22%)
megf11	XP_002938407.3	EMI	32..99	CDD:400092
		exchanger_TraA	<94..>311	CDD:411343	31/104 (30%)
		EGF_CA	759..804	CDD:419698	10/55 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561378at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010