DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7381 and si:ch211-221n20.8

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	XP_021324390.1	Gene:	si:ch211-221n20.8 / 100034409	ZFINID:	ZDB-GENE-041014-220	Length:	737	Species:	Danio rerio

Alignment Length:	753	Identity:	142/753 - (18%)
Similarity:	188/753 - (24%)	Gaps:	357/753 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GDGGVLAVFWPCETEADCTADGTSCDFASGQCECSTFDTVLAENFT---QCLATSLIG-EKCDDS 82
            ||.|      ||...|:||  .|...|.   |.|.....:..:..|   :|:..|:.| :.|...
Zfish    64 GDPG------PCGFHANCT--NTPGSFV---CRCHRGFLMSTDGCTDVDECVLASVTGLQACGSG 117

  Fly    83 VQCNLMP--TGASCKAGVCDCADGQNYL-------RGKCRPLNGLGESCETDLDCYFGYDRASVS 138
            .:|...|  ...||..|.....||||.:       ..:||  ..||..|......|
Zfish   118 AECKNTPGSFSCSCPEGFVLALDGQNCVDIDECNFEERCR--RELGNVCVNTAGSY--------- 171

  Fly   139 CQQNVCGCANGYYNRYGNICRRKSMEENDACVVNADCDELGAGVECVGLVCTYVDEITTTPGGET 203
                .|.|.:|:            .||..|||   |.|      |||
Zfish   172 ----TCVCLDGF------------REERTACV---DVD------ECV------------------ 193

  Fly   204 EETETTNPGSPEDDDSTTAEAITETADPEQETAFSSRRQLTKAFVHAPPPTHSDAAAQVSFAQLT 268
                                        ||......|
Zfish   194 ----------------------------EQPHLCDGR---------------------------- 202

  Fly   269 NGDTEPLISPRSHEIAVQTSIEKYELREVGRSVRNAATATTTTTATASTSTSSRRNSSRNQRHAH 333
             ||.|
Zfish   203 -GDCE------------------------------------------------------------ 206

  Fly   334 GQRRRLPALFRFDDEDIKTYSTLGSSRDDDDADEKKYGSSCTDNGKTCSGLPHSICSKN------ 392
                                :||||.|.......:..|:.|||..:..|| .|. |..|
Zfish   207 --------------------NTLGSYRCVCQRGYRGNGTHCTDINECLSG-DHG-CDVNARCGNI 249

  Fly   393 ----ICLCRQGYYARNGKCFAELGEIAESTDECEYEFDQL--TKTCNCQKNYFYERDLRN----- 446
                .|.|.|||......|: ::.|..:....||:.....  :.:|.|...|....||.|
Zfish   250 MGSYFCQCHQGYSGDGHACY-DVDECTQDNRLCEHTCTNQPGSYSCQCSAGYTITADLHNCTDVD 313

  Fly   447 -----------------------CRKPIQYHL---SCTSNSQC------------SPFGASYCHP 473
                                   ||:..|.|:   ||....:|            :..|...||.
Zfish   314 ECVSSNDRCEQTCTNTAGSFLCSCRRGFQLHIDGHSCVDIDECKLQNGGCSHECTNTEGGHQCHC 378

  Fly   474 EIP-----RRCTCEEYALYDAIKQLCEYKRGLGAECESNDGCPVDHSVCS----NRV-CVCADNY 528
            ..|     |..||....       .|..:.|         ||  || :||    :|: |.|...:
Zfish   379 PFPLLLDLRNTTCVNVT-------SCALRNG---------GC--DH-ICSLGAESRIHCSCRAGW 424

  Fly   529 FEKDDQCMRGIGADCSVEDDCIPENTECQEKDEEDQSR-TCQCRKGYVHFKDECLKEAEELEDEC 592
            ....||      ..|...|:|:..|..|::........ .|.||.|:...||...|
Zfish   425 ELSADQ------RTCIDVDECVSVNGGCEQVCVNHAGGFNCSCRAGFELRKDHPTK--------- 474

  Fly   593 VEDEQCKPLL-ASCNSEGKC---------------GCNDEQHAKNGVCETKRELGESCTKATECY 641
                 |:||. .:|.:.|.|               ||       :.:|......|.||.:...|.
Zfish   475 -----CQPLCDPACQNSGVCVAPNTCDCPAGYPGAGC-------SAMCSPPCAHGGSCMRWNVCL 527

  Fly   642 VEKDPENVECRNSVCQ--CKLGYSANANQNQCIRVMPN 677
            .........|..:||:  |       ||..:||  .||
Zfish   528 CSPGWTGEGCHTAVCELPC-------ANGGRCI--APN 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949	13/53 (25%)
		EB	101..155	CDD:279949	13/60 (22%)
		EB	570..624	CDD:279949	14/69 (20%)
		EB	613..665	CDD:279949	10/53 (19%)
si:ch211-221n20.8	XP_021324390.1	EGF_CA	57..>90	CDD:214542	12/36 (33%)
		cEGF	126..149	CDD:315355	7/22 (32%)
		EGF_CA	146..184	CDD:214542	11/64 (17%)
		EGF_CA	188..227	CDD:311536	17/199 (9%)
		EGF_3	233..268	CDD:315598	10/36 (28%)
		vWFA	<268..305	CDD:320736	7/37 (19%)
		vWFA	<309..347	CDD:320736	4/37 (11%)
		cEGF	332..355	CDD:315355	6/22 (27%)
		FXa_inhibition	356..391	CDD:317114	6/34 (18%)
		FXa_inhibition	397..433	CDD:317114	13/53 (25%)
		vWFA	<433..470	CDD:320736	9/36 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561378at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010