DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment grsm and loopin-1

DIOPT Version :9

Sequence 1:	NP_731749.3	Gene:	grsm / 41587	FlyBaseID:	FBgn0040493	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001097338.1	Gene:	loopin-1 / 36847	FlyBaseID:	FBgn0259795	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	588	Identity:	139/588 - (23%)
Similarity:	215/588 - (36%)	Gaps:	158/588 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 PACKPRSVNRCP-RKSSSNRSS--------RECMLMKSPKGM----------------ATDVKFN 130
            |:.|..|:.|.. |....|||.        |.....|||||:                |..|..:
  Fly     2 PSYKNMSLVRAGLRMVRQNRSGQSVIPSYRRYATSCKSPKGVVVGVYTKDGDKPSKTTANAVTLD 66

  Fly   131 ESLGCSDPQTHPVLIIGQLRHLNLLK-------------FSHLESKLSPRVTEETFLNAVACLHP 182
            ::||            |:|  |.|::             ||..|.:          ..|||.:..
  Fly    67 DALG------------GKL--LTLIRERGMDGTPGKGLLFSGFEGE----------YQAVAVVGV 107

  Fly   183 A-------PTDKVSLYLDVATVAALPLKASRHNTASRAHAITRLVKNHV--LNVSEESVVLVCER 238
            .       ..:::...::...|||        .|.:||..:..:.:.||  ::..|::..
  Fly   108 GKQGAAYNENEELDEGMENVRVAA--------GTGARALQLQGMYEVHVDSMDYPEQAAE----- 159

  Fly   239 ENLFASACAVVRAFPLYSRKTGNLLASSQPKLNL-GCGDGNANSGRNVVNVEFVLINKDGCIESE 302
                .:|.||.| :....||...:   ..|||:: |.||.:|          :|    .|..::|
  Fly   160 ----GAALAVWR-YNANKRKKNRI---QTPKLDMYGKGDRDA----------WV----RGLFKAE 202

  Fly   303 PLTDDELNCLNETTRAIRMTARIVDMPCNEMNVDHFIQEVEDVGRELC---ITPKVIRGEELLEQ 364
                           :..:..|:.|.|.|.|....|.|...|.   ||   ::.:|...:.:.:.
  Fly   203 ---------------SQNLARRLSDTPANMMTPSIFAQAAVDA---LCPCGVSVEVRSMDWIEDM 249

  Fly   365 GFGGIYGVGKAAAVPPALVVLSH---EPKGAQETIALVGKGIVYDTGGLSIKAKTGMPGMKRDCG 426
            .......:.|.:..||.|:..|:   .|:  ...:.|:|:|:.:.:|||.:|.||||...:....
  Fly   250 NLNSFLMIAKGSCEPPLLLECSYCGTTPE--DRPVLLLGQGLTFHSGGLCLKPKTGMDQYRGAMA 312

  Fly   427 GAAAILGTFYAAVQCGFRDNLHAVFCLAENSVGPNATRPDDIHTLYSGRTVEINNTDAEGRLVLA 491
            |||..:|...||.......|:.||..|.|:.....|.:..|:.||.:|.|:.|.|.|....:.||
  Fly   313 GAAVCVGVLRAAAALSLPLNITAVMPLCEHMPSGMAVKCGDVVTLLNGTTMGIKNVDKAPVVQLA 377

  Fly   492 DGVCYANKDLKANIILDMATLT-GAQGVATGKYHGAILTNSETWEAKSLQAGRKSGDLLAPIIYC 555
            |.:.||....|..:::|:.|:. |......|...|...|:...|     |..||||.|....::.
  Fly   378 DPLLYAQATYKPKLVIDIGTVAMGVNYAVGGGASGLWTTSKSVW-----QNFRKSGGLTGDRVWR 437

  Fly   556 PELHFSEFASAIADMKNSVADRQNA----QSSCAGLFIAAHLGFDYP-GIWMHVDMATPVHCGER 615
            ..| |..:...:  .||...|..|.    .|||   ..||.|....| ..|.|:|:        |
  Fly   438 FPL-FKYYKQIV--NKNITYDLCNTGRGPASSC---LAAAILHTLVPCAEWAHLDI--------R 488

  Fly   616 ATG 618
            .||
  Fly   489 GTG 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grsm	NP_731749.3	Peptidase_M17	141..628	CDD:238247	121/513 (24%)
loopin-1	NP_001097338.1	Peptidase_M17	41..518	CDD:238247	127/549 (23%)
loopin-1	NP_001097338.1	PRK00913	43..519	CDD:234863	125/547 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472724
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0260
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3211
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D562530at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.800