DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment grsm and S-Lap2

DIOPT Version :9

Sequence 1:	NP_731749.3	Gene:	grsm / 41587	FlyBaseID:	FBgn0040493	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_729394.1	Gene:	S-Lap2 / 326209	FlyBaseID:	FBgn0052351	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	140/568 - (24%)
Similarity:	223/568 - (39%)	Gaps:	124/568 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 SSNRSSRECML-MKSPKGMA----TDVKFNESLG------CSDPQTHPVLIIG------------ 147
            |.|..:|.|.| ::.|:.:.    .....|:.|.      |:||.:.. |::|
  Fly     5 SRNAITRACSLSIRRPEVIRHRRYASQAINQMLQLQQMEICADPPSRG-LVVGVYADEEDKNDAG 68

  Fly   148 -----------QLRHLNLLKFSHLESKLSPRVTEETFLNAVACLHPAPTDKVSLYLDVATVAALP 201
                       |..|..||:...:...: |:..|...|.||      ..::|..|..|| |..|.
  Fly    69 ILTPTGWKYNVQKTHGRLLEVLRMSGPM-PKRGETRLLFAV------EPERVPYYSAVA-VIGLG 125

  Fly   202 LKASRHNTASRAHAITRLVKNHVLNVSEESVVLVCERENLFASACAVVRAFPLYSRKTGNLLASS 266
            .:...:|            ...||:..:|::     |.:: |.||.::........:..|
  Fly   126 KECLGYN------------PYEVLDEQKEAI-----RRSV-ADACRILAELDTDRIEVEN----- 167

  Fly   267 QPKLNLGCGDGNANSGRNVVNVEFVLINKDG----CIESEPL--TDDELNCLNETTR-------A 318
                   ||...:.:....:.:......:|.    .:.|..|  |.||: |..|..|       |
  Fly   168 -------CGHAESAAEGAALGIWIYQELRDPKRRISVPSIDLYATKDEI-CDIEGWRIGLQKAAA 224

  Fly   319 IRMTARIVDMPCNEMNVDHFIQEVEDVGRELC-----ITPKVIRGEELLEQGFGGIYGVGKAAAV 378
            ..:|.::.:||.|.:....|.|.|.:|   ||     :..||....|  .|.......||||:..
  Fly   225 QNLTRQLQEMPSNLLTPTAFAQNVVEV---LCKSGVNVEVKVEGWAE--SQSMHAFLAVGKASCE 284

  Fly   379 PPALVVLSHEPKGAQE-TIALVGKGIVYDTGGLSIKAKTGMPGMKRDCGGAAAILGTFYAAVQCG 442
            ||..:.||:....|:| .|.|||:|:.||.|||.:|.|..:..|:.|..|||.::.|..|.....
  Fly   285 PPIFLELSYYGTCAEERPIVLVGQGVTYDAGGLCLKEKQELFHMRGDMTGAAVVVATCRAVAGLR 349

  Fly   443 FRDNLHAVFCLAENSVGPNATRPDDIHTLYSGRTVEINNTDAEGRLVLADGVCYANKDLKANIIL 507
            ...|:..:..|.||.:|.|:.||.|:....:|:|:|:..||.|..|||||.:.| .::.....|:
  Fly   350 LPVNIRGLIPLCENVIGCNSFRPGDMVKSMNGKTIEVQCTDHEDVLVLADALLY-GQNFCPKCII 413

  Fly   508 DMATLTGAQGVATGKYHGAILTNSETWEAKSLQAGRKSGDLL--APIIYCPELHFSEFASAI--- 567
            |:.|.:|....|..:....:.||||....:...|...:||.:  .|:       ::.::.|:
  Fly   414 DIGTCSGYMRQALDEAACGVFTNSEILWQQIKHASMHTGDRVWRFPL-------WNYYSKAVRAG 471

  Fly   568 --ADMKNSVADRQNAQSSCAGL---FIAAHLGFDYPGIWMHVDMATPV 610
              :|::|....|.......|..   |:..       |.|||:| ||.|
  Fly   472 GRSDVQNYGIGRGGRPCKAAAFLREFVPC-------GQWMHID-ATNV 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grsm	NP_731749.3	Peptidase_M17	141..628	CDD:238247	129/522 (25%)
S-Lap2	NP_729394.1	Peptidase_M17	52..538	CDD:238247	129/521 (25%)
S-Lap2	NP_729394.1	PRK00913	53..539	CDD:234863	129/519 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472719
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0260
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D562530at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11963
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1683
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.880