DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment grsm and Lap3

DIOPT Version :9

Sequence 1:	NP_731749.3	Gene:	grsm / 41587	FlyBaseID:	FBgn0040493	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001011910.1	Gene:	Lap3 / 289668	RGDID:	1307985	Length:	519	Species:	Rattus norvegicus

Alignment Length:	474	Identity:	113/474 - (23%)
Similarity:	191/474 - (40%)	Gaps:	118/474 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 DVATVAALPLKASRHNTASRAHAITRLVKNHVLNVSEESVVLVC----------------ERENL 241
            ::..::..||||.:..|.            :.|:....|||:|.                .:||:
  Rat    69 EMLNISGPPLKAGKTRTF------------YGLHQDFPSVVVVGLGKRSAGVDDQENWHEGKENI 121

  Fly   242 FASACAVVRAFPLYSRKTGNLLASSQPKLNLGCGDGNANSGRNVVNVEFVLINKDGCIESEPLTD 306
            .|:..|                         ||        |.|.::|...:..|.|.:::...:
  Rat   122 RAAVAA-------------------------GC--------RQVQDLELPSVEVDPCGDAQAAAE 153

  Fly   307 ---------DELNCLNETTRAIR---------------------MTARIVDMPCNEMNVDHFIQE 341
                     |:|....:...:.:                     :..::::.|.|||....|.:.
  Rat   154 GAVLGLYEYDDLKQKKKVAVSAKLHGSGDLEAWEKGVLFASGQNLARQLMESPANEMTPTRFAEV 218

  Fly   342 VEDVGRELCITPKV-IRGEELL-EQGFGGIYGVGKAAAVPPALVVLSH--EPKGAQETIALVGKG 402
            :|...:......:| ||.:..: ||..|....|.|.:..||..:.:.:  .|...:..:..||||
  Rat   219 IEKNLKSASSKTEVHIRTKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYTGSPNATEAPLVFVGKG 283

  Fly   403 IVYDTGGLSIKAKTGMPGMKRDCGGAAAILGTFYAAVQCGFRDNLHAVFCLAENSVGPNATRPDD 467
            |.:|:||:||||...|..|:.|.||||.|.....:|.:.....|:..:..|.||.....|.:|.|
  Rat   284 ITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGD 348

  Fly   468 IHTLYSGRTVEINNTDAEGRLVLADGVCYANKDLKANIILDMATLTGAQGVATGKYHGAILTNSE 532
            :....:|:|::::||||||||:|||.:|||: .....:|::.||||||..||.|.....:.|||.
  Rat   349 VVRARNGKTIQVDNTDAEGRLILADALCYAH-TFNPKVIINAATLTGAMDVALGSGATGVFTNSS 412

  Fly   533 TWEAKSLQAGRKSGDLL--APIIYCPELHFSEFASAIADMK----NSVADRQNAQSSCAGLFI-- 589
            ....|..:|..::||.:  .|:       |..:...:.|.:    |::...::|.:..|..|:
  Rat   413 WLWNKLFEASVETGDRVWRMPL-------FEHYTRQVIDCQLADVNNLGKYRSAGACTAAAFLRE 470

  Fly   590 -AAHLGFDYPGIWMHVDMA 607
             ..|..      |.|:|:|
  Rat   471 FVTHTK------WAHLDIA 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grsm	NP_731749.3	Peptidase_M17	141..628	CDD:238247	113/474 (24%)
Lap3	NP_001011910.1	Peptidase_M17	33..511	CDD:238247	113/474 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55148
OrthoDB	1	1.010	-	-		D562530at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830