DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and cyp2ad6

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001076405.1	Gene:	cyp2ad6 / 799957	ZFINID:	ZDB-GENE-041001-157	Length:	492	Species:	Danio rerio

Alignment Length:	496	Identity:	127/496 - (25%)
Similarity:	214/496 - (43%)	Gaps:	83/496 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYKSDIIGLHVGPFPVAVVHSADGVREI 90
            |:.|||||..:|:.|:  ....:|:|.:.:    |...| .:|..:.:|...:..|.....|:::
Zfish    34 PANFPPGPWPLPILGN--VFTDVNYKTVDQ----LIEKY-GNIFSVRIGSDKIVYVSGFKMVKDV 91

  Fly    91 L--NNQVFDGRPQLFVAAMRDPGQDVRGIFFQDGPLWKEQRRFILRYLRDFGFGRRFDQLELVIQ 153
            |  ..:.|..||   |:.:.|.....||:.|.:|..|::.::|.:.:|::||.||:  .||...|
Zfish    92 LITQGENFTDRP---VSPLFDTLYKGRGLSFNNGYSWRKHQQFSMSHLKNFGEGRK--TLEENNQ 151

  Fly   154 EQLNDMLDLIRNGPKYPHEHEMVKSGGYRVLLPLL-FNPFSANAHFYIVYNECLSREEMGKLVKL 217
            .:...:....:.....|.:             ||: .|...||...::|:.......::....:|
Zfish   152 RECYFLCGAFKEEQGRPFD-------------PLVKINNAVANVIGFLVFGHRYEYSDVNFQKRL 203

  Fly   218 CQMGIQFQRNADD-----------YGKMLSIIPWIRHIWPEW---SGYNKLNESNLFVRQFFADF 268
                   |.:|:.           |.....|:.|:.  .|..   |.|.||       ..|..:.
Zfish   204 -------QMSAESVFLTGSVWNQLYDAFPGIMKWVP--GPHQTIISNYQKL-------ANFLEEK 252

  Fly   269 VDKYLDSYEEGVERNFMDVYIAEMRRGPG---YGFNRDQLIMGLVDFSFPAFTAIGVQLSLLVQY 330
            ::::...::....|:::|.|:.|..:...   .||....|:..:||............|...:.:
Zfish   253 IEQHKPDWDISNPRDYIDAYLTEAEKKKNDTEAGFTVGSLVWSMVDLFEGGTETTTNTLRWALLF 317

  Fly   331 LMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLVPSDVPHKALEDTELL 395
            |:.||.:.::||.|||||:| .|||::.|:.|:.:..|.|.|.||...|||.::...|.:||.|.
Zfish   318 LIKYPDIQKKVQAEIDEVIG-SRLPSMSDKANMHYLNAFIHEVLRRANLVPLNMARVAKKDTTLG 381

  Fly   396 GYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSLPFGAGKRLCAGETFA 460
            ||.|.|.|:::.:|.:...|.:.|..|:.|.|:.|||::|..| :.:....|.||||.|.||..|
Zfish   382 GYFITKGTVMITNLTSVLYDKQEWETPDAFNPKHFLDSEGHFC-RRNAFFAFSAGKRQCPGEYLA 445

  Fly   461 RNMLFLVTATMCQHFDFVLGPNDRLPDLSQNLNGLIISPPD 501
            ...||:....:.|.|.|                    ||||
Zfish   446 HLELFIFLTILLQTFSF--------------------SPPD 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	125/492 (25%)
cyp2ad6	NP_001076405.1	p450	38..488	CDD:278495	125/492 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000