DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp2d26

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_083838.1	Gene:	Cyp2d26 / 76279	MGIID:	1923529	Length:	500	Species:	Mus musculus

Alignment Length:	510	Identity:	144/510 - (28%)
Similarity:	231/510 - (45%)	Gaps:	77/510 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LTICAAVFLCL------SYRYAVGRPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYK 65
            :.|..|:||.|      ..|:.    :.:||||...|..|:   :|.::|:.:..:...|...|
Mouse    12 VVIFTAIFLLLVDLVHRRQRWT----ACYPPGPVPFPGLGN---LLQVDFENIPYSFYKLQNRY- 68

  Fly    66 SDIIGLHVGPFPVAVVHSADGVREILNNQVFD--GRPQLFVAAMRDPGQDVRGIFFQD-GPLWKE 127
            .::..|.:...||.||:....|||:|.....|  .||.:.:......|...:|:.... ||.|:|
Mouse    69 GNVFSLQMAWKPVVVVNGLKAVRELLVTYGEDTSDRPLMPIYNHIGYGHKSKGVILAPYGPEWRE 133

  Fly   128 QRRFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYP-HEHEMVKSGGYRVLLPLLF-- 189
            ||||.:..|||||.|::  .||..:.|:...:.|......::| :...::......|:..|::
Mouse   134 QRRFSVSTLRDFGLGKK--SLEQWVTEEAGHLCDAFTKEAEHPFNPSPLLSKAVSNVIASLIYAR 196

  Fly   190 -----NPFSANAHFYIVYNECLS--REEMGKLVKLCQMGIQFQRNADDYGKMLSIIPWIRHI--W 245
                 :||         :|..|.  :|.:|:             :....|::|:.||.:.||  .
Mouse   197 RFEYEDPF---------FNRMLKTLKESLGE-------------DTGFVGEVLNAIPMLLHIPGL 239

  Fly   246 PEWSGYNKLNESNLFVRQFFADFVDKYLDSYEEGVE-----RNFMDVYIAEMRR---GPGYGFNR 302
            |: ..:.|||.        |...|:|.|..::...:     |:..|.::||:.:   .|...||.
Mouse   240 PD-KAFPKLNS--------FIALVNKMLIEHDSTWDPAQPPRDLTDAFLAEVEKAKGNPESSFND 295

  Fly   303 DQLIMGLVDFSFPAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTE 367
            ..|.:.::|............||..:..::|:|.|.|||..|||||:|..|.|.:.|:..:|:|.
Mouse   296 KNLRIVVIDLFMAGMVTTSTTLSWALLLMILHPDVQRRVHQEIDEVIGHVRHPEMADQARMPYTN 360

  Fly   368 ATIREGLRIETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLD 432
            |.|.|..|...:||:::||....|.:...:.|||.|.::|:|.:...|..:|..|.:|.||.|||
Mouse   361 AVIHEVQRFADIVPTNLPHMTSRDIKFQDFFIPKGTTLIPNLSSVLKDETVWEKPLRFYPEHFLD 425

  Fly   433 ADGKLCLKLDVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDFVLGPNDRLPD 487
            |.|.. :|.:..:||.||:|.|.||..||..|||....:.|.|.|      .:||
Mouse   426 AQGHF-VKHEAFMPFSAGRRSCLGEPLARMELFLFFTCLLQRFSF------SVPD 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	138/481 (29%)
Cyp2d26	NP_083838.1	p450	37..496	CDD:278495	138/481 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910