DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp2c65

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_082467.2	Gene:	Cyp2c65 / 72303	MGIID:	1919553	Length:	490	Species:	Mus musculus

Alignment Length:	518	Identity:	154/518 - (29%)
Similarity:	248/518 - (47%)	Gaps:	51/518 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MITETLLTICAAVFLCLSYRYAVGRPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYK 65
            |:....|.:.....|.||......:....||||..:|:.|:   :|.::.|.:.|:....|:.|
Mouse     1 MVLGVFLGLLLTCLLLLSLWRQNSQRRNLPPGPTPLPIIGN---ILQLDLKDISKSLRNFSKVY- 61

  Fly    66 SDIIGLHVGPFPVAVVHSADGVREIL--NNQVFDGRPQLFVAAMRDPGQDVRGIFFQDGPLWKEQ 128
            ..:..|::|..|..|:|..:.|:|..  :.:.|.||.   |..:.|..:...|:.|..|..|||.
Mouse    62 GPVFTLYLGRNPAVVLHGYEAVKEAFTDHGEEFAGRG---VFPVFDKFKKNCGVVFSSGRTWKEM 123

  Fly   129 RRFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHEMVKS-GGYRVLLPLLF-NP 191
            |||.|..||:||.|||  .:|..|||:...::|.:|.....|.:...:.. ....|:..::| |.
Mouse   124 RRFSLMTLRNFGMGRR--SIEDRIQEEARCLVDELRKTKGEPCDPTFILGCAPCNVICSIVFQNR 186

  Fly   192 FSANAHFYIVYNECLSREEMGKL----VKLCQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSGYN 252
            |......::.:.:.|: |.:..|    :::|          :::..::..:|. ||        .
Mouse   187 FDYKDQEFLTFLDILN-ENVEILSSPWIQIC----------NNFPAVIDYLPG-RH--------R 231

  Fly   253 KLNESNLFVRQFFADFVDKYLDSYEEGVERNFMDVYIAEM---RRGPGYGFNRDQLIMGLVDFSF 314
            ||:::..|...:|...|.::.:|.:....|:|:|.::.:|   :..|...|..:.|:....|. |
Mouse   232 KLHKNFAFAEHYFLSKVKQHQESLDINNPRDFIDCFLIKMEQEKHNPKTEFTCENLVFTASDL-F 295

  Fly   315 PA---FTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRI 376
            .|   .|:..::.|||:  |:.||.|..:||.|||.|:|..|.|.::||.::|:|:|.:.|..|.
Mouse   296 AAGTETTSTTLRYSLLL--LLKYPEVTAKVQEEIDCVIGRHRSPCMQDRHSMPYTDAVLHEIQRY 358

  Fly   377 ETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKL 441
            ..|:|:.:||....|.:...|.|||.|.|:.||.:...|.:.:.:||:|.|..|||..||. .|.
Mouse   359 IDLLPTSLPHAVTRDVKFREYLIPKGTTVIASLTSVLYDDKEFPNPEKFDPSHFLDERGKF-KKS 422

  Fly   442 DVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDFVLGPNDRLPDLSQN--LNGLIISPPDF 502
            |...||..|||:|.||..||..|||...|:.|:|: :..|.| |.||...  .||....||.|
Mouse   423 DYFFPFSTGKRICVGEGLARAELFLFLTTILQNFN-LKSPVD-LKDLDTTPVANGFASVPPKF 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	149/489 (30%)
Cyp2c65	NP_082467.2	p450	30..487	CDD:278495	149/489 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910