DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp2d22

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001156944.1	Gene:	Cyp2d22 / 56448	MGIID:	1929474	Length:	500	Species:	Mus musculus

Alignment Length:	475	Identity:	130/475 - (27%)
Similarity:	208/475 - (43%)	Gaps:	53/475 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 FPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYKSDIIGLHVGPFPVAVVHSADGVREILNN 93
            :||||...|:.|:.|.|...|.    .|.....|....|:..|.:....|.|::....:||.|..
Mouse    36 YPPGPMPWPVLGNLLHMDFQNM----PAGFQKLRGRYGDLFSLQLASESVVVLNGLTALREALVK 96

  Fly    94 QVFD--GRPQLFVAAMRDPGQDVRGIFF-QDGPLWKEQRRFILRYLRDFGFGRRFDQLELVIQEQ 155
            ...|  .||.|....:...|...:||.. :.||.|::||||.:..:..||.|::  .||..:.|:
Mouse    97 HSEDTADRPPLHFNDLLGFGPRSQGIVLARYGPAWRQQRRFSVSTMHHFGLGKK--SLEQWVTEE 159

  Fly   156 LNDMLDLIRNGPKYPHE-HEMVKSGGYRVLLPLLFNPFSANAHFYIVYNECLSREEMGKLVKLCQ 219
            ...:.....:...:|.. :.::......|:..||:              .|....:..:.::|
Mouse   160 ARCLCAAFADHTGHPFSPNTLLDKAVCNVIASLLY--------------ACRFEYDDPRFIRL-- 208

  Fly   220 MGIQFQRNADDYG---KMLSIIPWIRHIWPEWSGYNKLNESNLFV-RQFFADFVDKYLDSYEEGV 280
            :|:..:...::.|   ..|::.|.:..| |...|       .:|. ::.|...:|:.|..::...
Mouse   209 LGLLKETLKEEAGFLPMFLNVFPMLLRI-PGLVG-------KVFPGKRAFVTMLDELLAEHKTTW 265

  Fly   281 E-----RNFMDVYIAEMRR---GPGYGFNRDQLIMGLVDFSFPAFTAIGVQLSLLVQYLMLYPAV 337
            :     |:..|.::||:.:   .|...||.:.|...:.|............||..:..::|:|.|
Mouse   266 DPTQPPRDLTDAFLAEVEKAKGNPESSFNDENLRTVVGDLFSAGMVTTSTTLSWALMLMILHPDV 330

  Fly   338 LRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLVPSDVPHKALEDTELLGYRIPKD 402
            .||||.|||||:|..:.|.:.|:..:|:|.|.|.|..|...::|..||||...|.||.|:.|||.
Mouse   331 QRRVQQEIDEVIGQVQCPEMADQARMPYTNAVIHEVQRFADILPLGVPHKTSRDIELQGFLIPKG 395

  Fly   403 TIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSLPFGAGKRLCAGETFARNMLFLV 467
            |.::.:|.:...|..:|..|..|.||.||||.|.. :|.:..:||.||:|.|.||..||..|||.
Mouse   396 TTLITNLSSALKDETVWEKPLCFHPEHFLDAQGHF-VKPEAFMPFSAGRRSCLGEPLARMELFLF 459

  Fly   468 TATMCQHFDFVLGPNDRLPD 487
            ...:.|.|..      .:||
Mouse   460 FTCLLQRFSI------SVPD 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	130/474 (27%)
Cyp2d22	NP_001156944.1	p450	37..496	CDD:278495	130/474 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910