DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and cyp2x6

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001013583.1	Gene:	cyp2x6 / 541440	ZFINID:	ZDB-GENE-050320-144	Length:	491	Species:	Danio rerio

Alignment Length:	513	Identity:	156/513 - (30%)
Similarity:	246/513 - (47%)	Gaps:	42/513 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLTICAAVFLCLSYRYAVGRPSGFPPGPPKIPLFGSYLFMLIIN-FKYLHKAALTLSRWYKSDII 69
            |:.||   .|.:.:...|.:|..||||||.:|:|||.|.:.:.| .|...|.|...     .:|.
Zfish     7 LVVIC---ILLIFFLIRVKKPKNFPPGPPPVPIFGSLLQLNLANPLKDFEKFAEKY-----GEIF 63

  Fly    70 GLHVGPFPVAVVHSADGVREIL--NNQVFDGRPQLFVAAMRDPGQDVRGIFFQD-GPLWKEQRRF 131
            .|:.|..|..:::|...::|.|  ..|.|.||||.|   |.....:.:||...| ||:.|..|||
Zfish    64 SLYTGSRPAVILNSFAVIKEALVTKAQDFSGRPQDF---MISHATENKGIVLADYGPVLKGHRRF 125

  Fly   132 ILRYLRDFGFGRRFDQLELVIQEQLNDMLD-LIRNGPKYPHEHEMVKSGGYRVLLPLLFN-PFSA 194
            .|..:|:||.|::  .:|..|..:::.::| |.:|..|....|.|..:....|:..|||. .|..
Zfish   126 ALMTMRNFGLGKQ--SMEERILGEISHVVDYLDKNAGKRVDPHIMFHNVASNVISLLLFGCRFDY 188

  Fly   195 NAHFYIVYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSGYNKLNESNL 259
            |:.|...|.:.::  |:.|::.            ..:..:....|.:| |.|  ..:.|..:...
Zfish   189 NSEFLQCYIQLIN--EISKIIN------------GPWNMIYDTFPLLR-ILP--LPFKKAFDHVK 236

  Fly   260 FVRQFFADFVDKYLDSYEEGVERNFMDVYIAEMRRGPG--YGFNRDQLIMGLVDFSFPAFTAIGV 322
            .::......:|::..:...|..|:|:|.|:.|:.:|..  ..|:.|:|:|.::|..|.....|..
Zfish   237 VIKSMNLKLIDEHKSTRVPGEPRDFIDCYLDELDKGKNCVSTFSEDKLLMSIMDLHFAGTDTISN 301

  Fly   323 QLSLLVQYLMLYPAVLRRVQNEIDEVV-GCGRLPNLEDRKNLPFTEATIREGLRIETLVPSDVPH 386
            .|.....|||.:|.|..:.|.|||:|: |..|: ..|||.|:|:|.|.|.|..|:...||..|.|
Zfish   302 TLLTAFLYLMNHPEVQVKCQQEIDDVLEGKDRV-MYEDRHNMPYTLAVIHEVQRVANTVPLSVFH 365

  Fly   387 KALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSLPFGAGK 451
            ....||||:||.|||.||::|:|.....:...|..|.:|.|..||:..|:. .|.:..:||..|.
Zfish   366 STTRDTELMGYSIPKGTIIIPNLTRVLKEEGQWKFPYEFNPANFLNEQGQF-EKPEAFIPFSTGL 429

  Fly   452 RLCAGETFARNMLFLVTATMCQHFDFVLGPNDRLPDLSQNLNGLIISPPDFWLQLQDR 509
            |:|.||..||..|||:...:.:.|.|....:...||.:. :.||.::|..:.:.::.|
Zfish   430 RMCLGEGLARMELFLIFVALLRRFQFEWPVDAGKPDYTP-VFGLTLTPKPYRMHIRRR 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	148/482 (31%)
cyp2x6	NP_001013583.1	p450	36..479	CDD:278495	142/472 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000