DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp305a1

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	154/524 - (29%)
Similarity:	255/524 - (48%)	Gaps:	44/524 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLTICAAV--FLCLSYRYAVGRPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAA----LTLSRW- 63
            |:.:||.:  |:..|...:..||..|||||..:|..|:.|     .|:....|.    :...||
  Fly     4 LIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTL-----QFRKEASAVGGQHILFERWA 63

  Fly    64 --YKSDIIGLHVGPFPVAVVHSADGVREILNNQVFDGRPQLFVAAMRDPGQDVRGIFFQDGPLWK 126
              ::||::||.:|...|.|....:.|:|:...:||:|||..|...:|..|.. :||...||.||.
  Fly    64 KDFRSDLVGLKLGREYVVVALGHEMVKEVQLQEVFEGRPDNFFLRLRTMGTR-KGITCTDGQLWY 127

  Fly   127 EQRRFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHEMVKSGGYRVLLPLLFNP 191
            |.|.|.::.:|:.|:||  .|:|..|:.:..::|..:....:.|.|             |:.:..
  Fly   128 EHRHFAMKQMRNVGYGR--SQMEHHIELEAEELLGQLERTEEQPIE-------------PVTWLA 177

  Fly   192 FSA-NAHFYIVYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSGYNKLN 255
            .|. |..:.::..:.::|:|.|.|.:|..:..:..:..|..|.:|:..||:||:.|:.:|||.:.
  Fly   178 QSVLNVLWCLIAGKRIARQEDGTLRRLLDLMNRRSKLFDICGGLLAQFPWLRHVAPDRTGYNLIQ 242

  Fly   256 ESNLFVRQFFADFVDKY---LDSYEEGVERNFMDVYIAEMR----RGPGYGFNRDQLIMGLVDFS 313
            :.|..:..||.|.::::   |.......|.:.:..|:.||:    .|....||..||:|.::||.
  Fly   243 QLNTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFF 307

  Fly   314 FPAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCG---RLPNLEDRKNLPFTEATIREGLR 375
            ..........::|.:..|.:.|.|..::.:::...|...   ..|:|..|:...:.:|.|.|..|
  Fly   308 IAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQR 372

  Fly   376 IETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLK 440
            ...:.|...|.:||..|:|.||.|||:..::.||.:.|.|...|.||.:||||||:|:.|| |.|
  Fly   373 FFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGK-CFK 436

  Fly   441 LDVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDFVLGPNDRLPDLSQNLNGLIISPPDFWLQ 505
            .:..:|||.|:|.|.|:..||..:|.....:.|||..|| |....|.:.. |.|:.::|..:.:|
  Fly   437 DEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVL-PAGESPSMVL-LPGITLTPKPYKVQ 499

  Fly   506 LQDR 509
            ...|
  Fly   500 FVKR 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	144/491 (29%)
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	144/493 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457263
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47971at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3354
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24303
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
	6	5.950