Protein Alignment Cyp304a1 and Cyp2d12

DIOPT Version :10

• Sequence 1: NP_731751.1
• Gene: Cyp304a1 / 41586
• FlyBaseID: FBgn0038095
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_958748.1
• Gene: Cyp2d12 / 380997
• MGIID: 88604
• Length: 504
• Species: Mus musculus
• Alignment Length: 494
• Identity: 140/494 - (28%)
• Similarity: 227/494 - (45%)
• Gaps: 48/494 - (9%)

  Fly    27 SGFPPGPPKIPLFGSYLFMLIINFKY-LHKAALTLSRWYKSDIIGLHVGPFPVAVVHSADGVREI 90
            |.:||||...|:.|:.|.:.:.|..| |:|    |...| .|:..|.:...|:.|::....::|:
Mouse    34 SCYPPGPVPWPVLGNLLQVDLNNMPYSLYK----LQNRY-GDVFSLQMAWKPMVVINRMKAMKEV 93

  Fly    91 L---NNQVFDGRPQLFVAAMRDPGQDVRG---IFFQDGPLWKEQRRFILRYLRDFGFGRRFDQLE 149
            |   .....|..|   |......|...|.   ||...||.|:|||||.|..||:||.||:  .||
Mouse    94 LLTCGEDTADRPP---VPIFEHLGFKPRSQGMIFAPYGPEWREQRRFSLSSLRNFGLGRK--SLE 153

  Fly   150 LVIQEQLNDMLD-LIRNGPKYPHEHEMVKSGGYRVLLPLLFNPFSANAHFYIVYNECLSREEMGK 213
            ..:.::...:.| ......:|.:.:.|:|.....|:..|:|.........|::           :
Mouse   154 EWVIKEAGHLCDAFTTQAGQYINPNTMLKKATCNVIASLIFARRFEYEDPYLI-----------R 207

  Fly   214 LVKLCQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSGYNKLNESNLFVRQFFADFVDKYLDSYEE 278
            ::|:.:         |...::..:||.:.:.:|......:|.:..|..::.|...||..|.....
Mouse   208 MLKVLE---------DSLTELSGLIPEVINTFPILLHIPRLADKFLQSQKSFIAIVDNLLTENRT 263

  Fly   279 GVE-----RNFMDVYIAEMRR---GPGYGFNRDQLIMGLVDFSFPAFTAIGVQLSLLVQYLMLYP 335
            ..:     ||..|.::||:.:   .|...||.:.|.|.::|............||..:..::|:|
Mouse   264 TWDPAQSPRNLTDAFLAEIEKAKGNPESSFNDENLRMVVIDLFTAGILTTSTTLSWALLLMILHP 328

  Fly   336 AVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLVPSDVPHKALEDTELLGYRIP 400
            .|.||||.|||||:|..|.|.:.|:.::|:|.|.|.|..|...:||..:|.....|.|:..:.||
Mouse   329 DVQRRVQQEIDEVIGQVRHPEMADQAHMPYTNAVIHEVQRFGDIVPLHLPRITSRDIEVQDFLIP 393

  Fly   401 KDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSLPFGAGKRLCAGETFARNMLF 465
            |.||::|::.:.|.|..:|..|.:|.||.||||.|.. :|.:..:.|.||:|.|.||..||..||
Mouse   394 KGTILLPNMSSVHMDDTVWEKPLRFHPEHFLDAQGHF-VKHEAFITFSAGRRSCLGEPLARMELF 457

  Fly   466 LVTATMCQHFDFVLGPNDRLPDLSQNLNGLIISPPDFWL 504
            |....:.|.|.|.: |:.:.......:..::::|..:.|
Mouse   458 LFFTCLLQRFSFSV-PDGQPQPSDHRVFSIMVAPSPYQL 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	CYP15A1-like	66..504	CDD:410744	125/452 (28%)
Cyp2d12	NP_958748.1	CYP2D	68..495	CDD:410756	126/454 (28%)