DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp2s1

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001100965.1	Gene:	Cyp2s1 / 308445	RGDID:	1306078	Length:	499	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	155/517 - (29%)
Similarity:	243/517 - (47%)	Gaps:	44/517 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TETLLTICAAVFLCLSYRYAVGRPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYKSD 67
            |..||.....:.|.|:......| ...||||..:||.|:   :|.:....|:...|.||:.| ..
  Rat     6 TWALLLALLLLLLALTLPRTPAR-GQLPPGPTPLPLLGN---LLQLRPGALYSGFLRLSKKY-GP 65

  Fly    68 IIGLHVGPF-PVAVVHSADGVREILNNQV--FDGRPQLFVAAMRDPGQDVRGIFFQDGPLWKEQR 129
            :..:|:||: .|.|:...|.:||.|..|.  |.||..|   |..|...|..|:||.:|..||:.|
  Rat    66 VFTVHLGPWRRVVVLVGHDAIREALGGQAEEFSGRGTL---ATLDKTFDGHGVFFANGERWKQLR 127

  Fly   130 RFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHEM-VKSGGYRVLLPLLFN--- 190
            :|.|..|||.|.|:|  :.|.:|||::.:::...:.....|....| :......|:..|:|.
  Rat   128 KFTLLALRDLGMGKR--EGEELIQEEVQNLVKAFQRTEGRPFNPSMLLAQATSNVVCSLIFGIRL 190

  Fly   191 PFSANAHFYIVYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSGYNKLN 255
            |:. :..|     :.:.:...|.|     :||     :..:|:...:..|:  :.|....:.:|.
  Rat   191 PYE-DKEF-----QAVIQAASGTL-----LGI-----SSPWGQAYEMFSWL--LQPLPGPHTQLQ 237

  Fly   256 ESNLFVRQFFADFVDKYLD-SYEEGVERNFMDVYIAEM---RRGPGYGFNRDQLIMGLVDFSFPA 316
            .....:..|....|.::.. |:..|..|:.:|.::.:|   :..||..|....|:|.:....|..
  Rat   238 HHLGTLAAFTIQQVQRHQGRSHTSGPARDVVDAFLQKMAQEKEDPGTEFTEKNLLMTVTYLLFAG 302

  Fly   317 FTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLVP 381
            ...||..:...:..|:.||.|.:||:.|:.:.:|..|.|:|.||..||:|:|.:.|..|:..|||
  Rat   303 TMTIGATIRYALLLLLKYPQVQKRVREELIQELGPSRTPSLSDRVRLPYTDAVLHEAQRLLALVP 367

  Fly   382 SDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSLP 446
            ..:||...:.|...||.:||.|.|.|.:.:...|..::.:||:|.|.||||.||:: .|.:..||
  Rat   368 MGMPHTVTKTTSFRGYTLPKGTEVFPLIGSVLHDPAVFRNPEEFHPSRFLDDDGRI-RKHEAFLP 431

  Fly   447 FGAGKRLCAGETFARNMLFLVTATMCQHF--DFVLGPNDRLPDLSQNLNGLIISPPDFWLQL 506
            :..|||:|.||..||..|:|...::.|.|  |....|.|.  .|...:.||...||||.||:
  Rat   432 YSLGKRVCLGEGLARAELWLFFTSILQAFSLDTPCPPGDL--SLKPAVRGLFNIPPDFQLQV 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	147/486 (30%)
Cyp2s1	NP_001100965.1	p450	48..491	CDD:365848	140/469 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910