DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp304a1 and CYP2S1

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_085125.1	Gene:	CYP2S1 / 29785	HGNCID:	15654	Length:	504	Species:	Homo sapiens

Alignment Length:	524	Identity:	153/524 - (29%)
Similarity:	244/524 - (46%)	Gaps:	54/524 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LTICAAVFLCLSYRYAVGRPSG-FPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYKSDIIG 70
            |.:..|:.|.|:...:..|..| .||||..:||.|:   :|.:....|:...:.||:.| ..:..
Human     9 LLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGN---LLQLRPGALYSGLMRLSKKY-GPVFT 69

  Fly    71 LHVGPF-PVAVVHSADGVREILNNQV--FDGRPQLFVAAMRDPGQDVRGIFFQDGPLWKEQRRFI 132
            :::||: ||.|:...:.|||.|..|.  |.||.   ..||.:...|..|:||.:|..|::.|:|.
Human    70 IYLGPWRPVVVLVGQEAVREALGGQAEEFSGRG---TVAMLEGTFDGHGVFFSNGERWRQLRKFT 131

  Fly   133 LRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHE-MVKSGGYRVLLPLLFN-PFSAN 195
            :..|||.|.|:|  :.|.:||.:...:::..:.....|.:.. ::......|:..|||. .||..
Human   132 MLALRDLGMGKR--EGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYE 194

  Fly   196 AHFYIVYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSGYNKL---NES 257
            ...:    :.:.|...|.|:.:...|          |:...:..|.....|   |.:|.   :.|
Human   195 DKEF----QAVVRAAGGTLLGVSSQG----------GQTYEMFSWFLRPLP---GPHKQLLHHVS 242

  Fly   258 NLFVRQFFADFVDKYLDSYE-----EGVERNFMDVYIAEM---RRGPGYGFNRDQLIMGLVDFSF 314
            .|      |.|..:.:..::     .|..|:.:|.::.:|   .:.||..|....::|.::...|
Human   243 TL------AAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLF 301

  Fly   315 PAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETL 379
            .....:...:...:..||.||.|.:.|:.|::..:|.|:.|:|.||..||:|:|.:.|..|:..|
Human   302 AGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLAL 366

  Fly   380 VPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVS 444
            ||..:|...:..|...||.:|:.|.|.|.|.:...|..|:..||:|.|:|||||||:. .|.:..
Human   367 VPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRF-RKHEAF 430

  Fly   445 LPFGAGKRLCAGETFARNMLFLVTATMCQHFDFVLG-PNDRLPDLSQNLNGLIISPPDFWLQLQ- 507
            |||..|||:|.||..|:..|||...|:.|.|..... |.|.| .|...::||...||.|.||::
Human   431 LPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTL-SLKPTVSGLFNIPPAFQLQVRP 494

  Fly   508 -DRH 510
             |.|
Human   495 TDLH 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	143/490 (29%)
CYP2S1	NP_085125.1	p450	49..488	CDD:365848	134/469 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910