DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp2c6v1

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001013926.2	Gene:	Cyp2c6v1 / 293989	RGDID:	619934	Length:	490	Species:	Rattus norvegicus

Alignment Length:	516	Identity:	155/516 - (30%)
Similarity:	251/516 - (48%)	Gaps:	55/516 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLTICAAVFLCLSYRYAVGRPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYKSDIIG 70
            :||:...:.|.: :|.:.|| ...||||..:|:.|: :|.|  |.|.:.::..:.|:.| ..:..
  Rat     8 VLTLTCLILLSI-WRQSSGR-GKLPPGPIPLPIIGN-IFQL--NVKNITQSLTSFSKVY-GPVFT 66

  Fly    71 LHVGPFPVAVVHSADGVREIL--NNQVFDGRPQLFVAAMRDPGQDVRGIFFQDGPLWKEQRRFIL 133
            |:.|..|..::|..:.|:|.|  :.:.|..|....||  ....:|: ||.|..|..|||.|||.|
  Rat    67 LYFGTKPTVILHGYEAVKEALIDHGEEFAERGSFPVA--EKINKDL-GIVFSHGNRWKEIRRFTL 128

  Fly   134 RYLRDFGFGRRFDQLELVIQEQLNDMLDLIR--NG----PKYPHEHEMVKSGGYRVLLPLLF-NP 191
            ..||:.|.|:|  .:|..:||:...:::.:|  ||    |.:     ::......|:..::| |.
  Rat   129 TTLRNLGMGKR--NIEDRVQEEARCLVEELRKTNGSPCDPTF-----ILGCAPCNVICSIIFQNR 186

  Fly   192 FSANAHFYIVYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSGYNKLNE 256
            |......::...|.|: |.|..|             :..:.:..|..|.:....|  ..:..|.:
  Rat   187 FDYKDQDFLNLMEKLN-ENMKIL-------------SSPWTQFCSFFPVLIDYCP--GSHTTLAK 235

  Fly   257 SNLFVRQFFADFVDKYLDSYEEGVERNFMDVYIAEMRR---GPGYGFNRDQLIMGLVDFSFPA-- 316
            :...:|.:....:.::.:|.:....|:|:|.|:.:.::   .|...|..:.|.:.:.|. |.|
  Rat   236 NVYHIRNYLLKKIKEHQESLDVTNPRDFIDYYLIKWKQENHNPHSEFTLENLSITVTDL-FGAGT 299

  Fly   317 -FTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLV 380
             .|:..::.:||:  |:..|.|..:||.|||.|||..|.|.::||..:|:|:|.|.|..|...|:
  Rat   300 ETTSTTLRYALLL--LLKCPEVTAKVQEEIDRVVGKHRSPCMQDRSRMPYTDAMIHEVQRFIDLI 362

  Fly   381 PSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSL 445
            |:::||....|.:...|.|||.|.::.||.:...|::.:.|||.|.|..|||.:||. .|.|..:
  Rat   363 PTNLPHAVTCDIKFRNYLIPKGTTIITSLSSVLHDSKEFPDPEIFDPGHFLDGNGKF-KKSDYFM 426

  Fly   446 PFGAGKRLCAGETFARNMLFLVTATMCQHFDF--VLGPNDRLPDLSQNLNGLIISPPDFWL 504
            ||.||||:||||..||..|||...|:.|:|..  ||.|.|  .|.:...||....||.:.|
  Rat   427 PFSAGKRMCAGEGLARMELFLFLTTILQNFKLKSVLHPKD--IDTTPVFNGFASLPPFYEL 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	148/490 (30%)
Cyp2c6v1	NP_001013926.2	CYP2C-like	61..485	CDD:410758	137/456 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000