Protein Alignment Cyp304a1 and Cyp2c6

DIOPT Version :10

• Sequence 1: NP_731751.1
• Gene: Cyp304a1 / 41586
• FlyBaseID: FBgn0038095
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001013926.2
• Gene: Cyp2c6 / 293989
• RGDID: 619934
• Length: 490
• Species: Rattus norvegicus
• Alignment Length: 516
• Identity: 155/516 - (30%)
• Similarity: 251/516 - (48%)
• Gaps: 55/516 - (10%)

  Fly     6 LLTICAAVFLCLSYRYAVGRPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYKSDIIG 70
            :||:...:.|.: :|.:.|| ...||||..:|:.|: :|.|  |.|.:.::..:.|:.| ..:..
  Rat     8 VLTLTCLILLSI-WRQSSGR-GKLPPGPIPLPIIGN-IFQL--NVKNITQSLTSFSKVY-GPVFT 66

  Fly    71 LHVGPFPVAVVHSADGVREIL--NNQVFDGRPQLFVAAMRDPGQDVRGIFFQDGPLWKEQRRFIL 133
            |:.|..|..::|..:.|:|.|  :.:.|..|....||  ....:|: ||.|..|..|||.|||.|
  Rat    67 LYFGTKPTVILHGYEAVKEALIDHGEEFAERGSFPVA--EKINKDL-GIVFSHGNRWKEIRRFTL 128

  Fly   134 RYLRDFGFGRRFDQLELVIQEQLNDMLDLIR--NG----PKYPHEHEMVKSGGYRVLLPLLF-NP 191
            ..||:.|.|:|  .:|..:||:...:::.:|  ||    |.:     ::......|:..::| |.
  Rat   129 TTLRNLGMGKR--NIEDRVQEEARCLVEELRKTNGSPCDPTF-----ILGCAPCNVICSIIFQNR 186

  Fly   192 FSANAHFYIVYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSGYNKLNE 256
            |......::...|.|: |.|..|             :..:.:..|..|.:....|  ..:..|.:
  Rat   187 FDYKDQDFLNLMEKLN-ENMKIL-------------SSPWTQFCSFFPVLIDYCP--GSHTTLAK 235

  Fly   257 SNLFVRQFFADFVDKYLDSYEEGVERNFMDVYIAEMRR---GPGYGFNRDQLIMGLVDFSFPA-- 316
            :...:|.:....:.::.:|.:....|:|:|.|:.:.::   .|...|..:.|.:.:.|. |.|
  Rat   236 NVYHIRNYLLKKIKEHQESLDVTNPRDFIDYYLIKWKQENHNPHSEFTLENLSITVTDL-FGAGT 299

  Fly   317 -FTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLV 380
             .|:..::.:||:  |:..|.|..:||.|||.|||..|.|.::||..:|:|:|.|.|..|...|:
  Rat   300 ETTSTTLRYALLL--LLKCPEVTAKVQEEIDRVVGKHRSPCMQDRSRMPYTDAMIHEVQRFIDLI 362

  Fly   381 PSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSL 445
            |:::||....|.:...|.|||.|.::.||.:...|::.:.|||.|.|..|||.:||. .|.|..:
  Rat   363 PTNLPHAVTCDIKFRNYLIPKGTTIITSLSSVLHDSKEFPDPEIFDPGHFLDGNGKF-KKSDYFM 426

  Fly   446 PFGAGKRLCAGETFARNMLFLVTATMCQHFDF--VLGPNDRLPDLSQNLNGLIISPPDFWL 504
            ||.||||:||||..||..|||...|:.|:|..  ||.|.|  .|.:...||....||.:.|
  Rat   427 PFSAGKRMCAGEGLARMELFLFLTTILQNFKLKSVLHPKD--IDTTPVFNGFASLPPFYEL 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	CYP15A1-like	66..504	CDD:410744	136/454 (30%)
Cyp2c6	NP_001013926.2	CYP2C-like	61..485	CDD:410758	137/456 (30%)