DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp2c11

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_062057.2	Gene:	Cyp2c11 / 29277	RGDID:	2469	Length:	500	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	139/485 - (28%)
Similarity:	240/485 - (49%)	Gaps:	49/485 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLTICAAVFLCLSYRYAVGRPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYKSDIIG 70
            :||:.:.:.|.| :|.:.|| ...||||..:|:.|:   .|.|..|.:.::....|:.| ..|..
  Rat     8 VLTLSSLLLLSL-WRQSFGR-GKLPPGPTPLPIIGN---TLQIYMKDIGQSIKKFSKVY-GPIFT 66

  Fly    71 LHVGPFPVAVVHSADGVREILNN--QVFDGRPQLFVAAMRDPGQDVRGIFFQDGPLWKEQRRFIL 133
            |::|..|..|:|..:.|:|.|.:  :.|.||....|:...:.|   .|:.|.:|..|||.|||.:
  Rat    67 LYLGMKPFVVLHGYEAVKEALVDLGEEFSGRGSFPVSERVNKG---LGVIFSNGMQWKEIRRFSI 128

  Fly   134 RYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHEMVKS-GGYRVLLPLLF-NPFSANA 196
            ..||.||.|:|  .:|..|||:...:::.:|.....|.:...:.. ....|:..::| |.|....
  Rat   129 MTLRTFGMGKR--TIEDRIQEEAQCLVEELRKSKGAPFDPTFILGCAPCNVICSIIFQNRFDYKD 191

  Fly   197 HFYI----VYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSGYNKLNES 257
            ..::    .:||                  .|:..:..:.::.:..|.|...:|  ..:|::.::
  Rat   192 PTFLNLMHRFNE------------------NFRLFSSPWLQVCNTFPAIIDYFP--GSHNQVLKN 236

  Fly   258 NLFVRQFFADFVDKYLDSYEEGVERNFMDVYIAEM---RRGPGYGFNRDQLIMGLVDFSFPA--- 316
            ..:::.:..:.|.::.:|.::...|:|:|.::.:|   :..|...|..:.|:..:.|. |.|
  Rat   237 FFYIKNYVLEKVKEHQESLDKDNPRDFIDCFLNKMEQEKHNPQSEFTLESLVATVTDM-FGAGTE 300

  Fly   317 FTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLVP 381
            .|:..::..||:  |:.:..|..:||.||:.|:|..|.|.::||..:|:|:|.:.|..|...|||
  Rat   301 TTSTTLRYGLLL--LLKHVDVTAKVQEEIERVIGRNRSPCMKDRSQMPYTDAVVHEIQRYIDLVP 363

  Fly   382 SDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSLP 446
            :::||....|.:...|.|||.|.|:.||.:...|.:.:.:||:|.|..|||..|.. .|.|..:|
  Rat   364 TNLPHLVTRDIKFRNYFIPKGTNVIVSLSSILHDDKEFPNPEKFDPGHFLDERGNF-KKSDYFMP 427

  Fly   447 FGAGKRLCAGETFARNMLFLVTATMCQHFD 476
            |.||||:||||..||..|||...|:.|:|:
  Rat   428 FSAGKRICAGEALARTELFLFFTTILQNFN 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	132/461 (29%)
Cyp2c11	NP_062057.2	p450	30..487	CDD:278495	132/461 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910