DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp2w1

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_038945900.1	Gene:	Cyp2w1 / 288517	RGDID:	1305193	Length:	492	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	142/526 - (26%)
Similarity:	222/526 - (42%)	Gaps:	82/526 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLTICAAVFLCLSYRYAVGR-----PS---GFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSR 62
            ||.:|....|.|...:.:.|     ||   .:||||..:|..|:   :.::...:..:|.:.||.
  Rat     3 LLVLCVWGILLLLGLWGLLRGCAQDPSMTRQWPPGPRPLPFLGN---LHLLGVTHQDRALMELSE 64

  Fly    63 WYKSDIIGLHVGPFPVAVVHSADGVREIL---NNQVFDGRPQLFVAAMRDPGQDVRGIFFQDGPL 124
            .| ..:..:|:|.....|:...:.|||.|   .:::.| ||.:.:..:...|   .||||..|..
  Rat    65 RY-GPMFTIHLGSQKTVVLSGYEVVREALVGTGHELAD-RPPIPIFQLIQRG---GGIFFSSGVH 124

  Fly   125 WKEQRRFILRYLRDFGFGRRFDQLELVIQEQ--LNDMLDLIRNGPKYPHEHEMVKSGGYRVLLPL 187
            ||..|:|.:|.|:..|. |:...:..|:||.  |...||               ..||....|.|
  Rat   125 WKVARQFTVRTLQSLGI-RQPPMVGKVLQELVCLKGQLD---------------SYGGQPFPLTL 173

  Fly   188 L-FNPFSANAHFYIVYNECLSREEM----------GKLVKLCQMGIQFQRNADDYGKMLSIIPWI 241
            | :.|  .|..|.:::.:....::.          ..:|.|...|||........|.:|.:...:
  Rat   174 LGWAP--CNITFTLLFGQRFDYQDPVFVSLLSLIDQVMVLLGSPGIQLFNTFPRLGALLRLHRPV 236

  Fly   242 RHIWPEWSGYNKLNESNLFVRQFFADFVDKYLDSYEEG-VERNFMDVYIAEMRRGPGYGFNRDQL 305
                     .:|:.|    ||......::........| ..|::::..:.:.:..|...|:...:
  Rat   237 ---------LSKIEE----VRTILRTLLEAQRPPLPNGSPARSYVEALLQQGQDDPEDMFSEANV 288

  Fly   306 IMGLVDFSFPAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATI 370
            :...:|............|...|..::.:|.|..|||.|:|.|:|.|:||..||::.||:|.|.:
  Rat   289 LACTLDMVMAGTETTAATLQWAVFLMVKHPHVQGRVQEELDRVLGPGQLPQPEDQRALPYTSAVL 353

  Fly   371 REGLRIETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADG 435
            .|..|..||:| .||.....|.:|.||.:||.|.|:|.|.:...|...|..|.||.|..||||.|
  Rat   354 HEVQRYITLLP-HVPRCTAADIQLGGYLLPKGTPVIPLLTSVLLDKTQWETPSQFNPNHFLDAKG 417

  Fly   436 KLC-LKLDVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDFVLGPNDRLPDLSQNLNGLIISP 499
              | :|....|||..|:|:|.||:.||..|||:.|.:.|.:..:..|.              :||
  Rat   418 --CFMKRGAFLPFSTGRRVCVGESLARTELFLLFAGLLQQYHLLPPPG--------------LSP 466

  Fly   500 PDFWLQ 505
            .|..|:
  Rat   467 ADLDLR 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	133/491 (27%)
Cyp2w1	XP_038945900.1	cytochrome_P450	66..486	CDD:425388	125/460 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000