Protein Alignment Cyp304a1 and Cyp17a1

DIOPT Version :10

• Sequence 1: NP_731751.1
• Gene: Cyp304a1 / 41586
• FlyBaseID: FBgn0038095
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_036885.2
• Gene: Cyp17a1 / 25146
• RGDID: 2456
• Length: 507
• Species: Rattus norvegicus
• Alignment Length: 540
• Identity: 153/540 - (28%)
• Similarity: 236/540 - (43%)
• Gaps: 90/540 - (16%)

  Fly    13 VFLCLSYRYAV-GRPSG--FPPGPPKIPLFGSYLFM-----LIINFKYLHKAALTLSRWYKSDII 69
            :.|.|:|.:.| .:..|  .|...|.:||.||..|:     :.:||       ..|...| ..|.
  Rat     8 LLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNF-------FKLQEKY-GPIY 64

  Fly    70 GLHVGPFPVAVVHSADGVREIL--NNQVFDGRPQLFV-AAMRDPGQDVRGIFFQD-GPLWKEQRR 130
            .|.:|.....::......||:|  ..:.|.||||:.. :.:.|.|   :|:.|.| |..|...|:
  Rat    65 SLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQG---KGVAFADAGSSWHLHRK 126

  Fly   131 FILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHEMVKSGGYRVLLPLLFNPFSAN 195
            .:......|..|::   ||.:|.::...:.|::     ..|:.|.:.     :..|:..:  ..|
  Rat   127 LVFSTFSLFKDGQK---LEKLICQEAKSLCDMM-----LAHDKESID-----LSTPIFMS--VTN 176

  Fly   196 AHFYIVYNECLSREEMGKL--VKLCQMGIQFQRNADDYG--KMLSIIPWIRHIWPE-----WSGY 251
            ....|.:|....::: .||  :|....||     .|..|  .::.|.||:. |:|.     ..||
  Rat   177 IICAICFNISYEKKD-PKLTAIKTFTEGI-----VDATGDRNLVDIFPWLT-IFPNKGLEVIKGY 234

  Fly   252 NKLNESNLFVRQFFADFVDKYLDSYEEGVERNFMDVYI-AEMR---------RGPGYGFNRDQLI 306
            .|:.      .:......:|..:.::.....:..|:.| |:|.         |.|.. |: |:.|
  Rat   235 AKVR------NEVLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDV-FS-DRHI 291

  Fly   307 MGLVDFSFPAFTAIGVQ-----LSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFT 366
            :..|...|.|    |::     |..::.:|:..|.|.:::|.|||:.||..|.|...||.:|...
  Rat   292 LATVGDIFGA----GIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLML 352

  Fly   367 EATIREGLRIETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFL 431
            ||||||.|||..:.|..:||||..|:.:..:.:||||.||.:|:|.|.|...|..|:||.|||||
  Rat   353 EATIREVLRIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFL 417

  Fly   432 DADGK-LCLKLDVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDFVLGPNDRLPDLSQNLNGL 495
            |..|. |.......||||||.|.|.||..||..||:.||.:.|.||..:..:.:||.|..:...:
  Rat   418 DPTGSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPKVV 482

  Fly   496 IISPP--------DFWLQLQ 507
            .:..|        ..|:..|
  Rat   483 FLIDPFKVKITVRQAWMDAQ 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	CYP15A1-like	66..504	CDD:410744	135/474 (28%)
Cyp17a1	NP_036885.2	CYP17A1	60..490	CDD:410766	136/467 (29%)