DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp2e1

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_113731.2	Gene:	Cyp2e1 / 25086	RGDID:	2475	Length:	493	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	155/520 - (29%)
Similarity:	250/520 - (48%)	Gaps:	55/520 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ITETLLTICAAVFLCLSYRYAVGRPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYKS 66
            ||..|| :..|..|.:|....:......||||..:|:.|: :|.|  :.|.:.|:...|::.: .
  Rat     6 ITIALL-VWVATLLVISIWKQIYNSWNLPPGPFPLPILGN-IFQL--DLKDIPKSFTKLAKRF-G 65

  Fly    67 DIIGLHVGPFPVAVVHSADGVREILNN--QVFDGRPQLFVAAMRDPGQDV--RGIFFQDGPLWKE 127
            .:..||:|...:.|:|....|:|:|.|  ..|.||..:.|.      |:.  :||.|.:||.||:
  Rat    66 PVFTLHLGSRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVF------QEYKNKGIIFNNGPTWKD 124

  Fly   128 QRRFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHE-MVKSGGYRVLLPLLFNP 191
            .|||.|..|||:|.|::.:  |..||.:...:::.::.....|.:.. ::......|:..:|||.
  Rat   125 VRRFSLSILRDWGMGKQGN--EARIQREAQFLVEELKKTKGQPFDPTFLIGCAPCNVIADILFNK 187

  Fly   192 -FSAN----AHFYIVYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSGY 251
             |..|    .....::||        ....|....||...|..||   |..:|         ..:
  Rat   188 RFDYNDKKCLRLMSLFNE--------NFYLLSTPWIQLYNNFADY---LRYLP---------GSH 232

  Fly   252 NKLNESNLFVRQFFADFVDKYLDSYEEGVERNFMDVYIAEMRR-----GPGYGFNRDQLIMGLVD 311
            .|:.::...::|:..:...::|.|.:....|:..|..:.||.:     .|.|......:.:..:.
  Rat   233 RKIMKNVSEIKQYTLEKAKEHLQSLDINCARDVTDCLLIEMEKEKHSQEPMYTMENVSVTLADLF 297

  Fly   312 FSFPAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRI 376
            |:....|:..::..||:  ||.||.:..::..|||.|:|..|:|.:.||.::|:.:|.:.|..|.
  Rat   298 FAGTETTSTTLRYGLLI--LMKYPEIEEKLHEEIDRVIGPSRVPAVRDRLDMPYMDAVVHEIQRF 360

  Fly   377 ETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKL 441
            ..||||::||:|..||...||.|||.|:|:|:|.:...|:..:.|||:|:||.||:.:||....
  Rat   361 INLVPSNLPHEATRDTVFQGYVIPKGTVVIPTLDSLLYDSHEFPDPEKFKPEHFLNENGKFKYS- 424

  Fly   442 DVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDF--VLGPNDRLPDLSQNLNGLIISPPDFWL 504
            |....|.||||:|.||..||..|||:.:.:.|||:.  ::.|.|  .|||....|....||.|.|
  Rat   425 DYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKD--IDLSPVTVGFGSIPPQFKL 487

Fly 505 504
Rat 488 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	147/490 (30%)
Cyp2e1	NP_113731.2	CYP2C-like	64..487	CDD:410758	136/456 (30%)
Cyp2e1	NP_113731.2	Substrate binding. /evidence=ECO:0000250	298..303		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910