DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp2c12

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_113760.2	Gene:	Cyp2c12 / 25011	RGDID:	2470	Length:	490	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	138/523 - (26%)
Similarity:	239/523 - (45%)	Gaps:	66/523 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLTICAAVFLCLSYRYAVGRPS----GFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYKS 66
            ::.:.:..||.|.|.:   |||    ..||||..:|:||::   |.|:.|.:.::....|:.| .
  Rat     5 VVLVLSLSFLLLLYLW---RPSPGRGKLPPGPTPLPIFGNF---LQIDMKDIRQSISNFSKTY-G 62

  Fly    67 DIIGLHVGPFPVAVVHSADGVREIL--NNQVFDGRPQLFVAAMRDPGQDVRGIFFQDGPLWKEQR 129
            .:..|:.|..|..|:|..:.|:|.|  ..:.|.||.::.|......|   .||.|..|.:|:..|
  Rat    63 PVFTLYFGSQPTVVLHGYEAVKEALIDYGEEFSGRGRMPVFEKATKG---LGISFSRGNVWRATR 124

  Fly   130 RFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRN------GPKYPHEHEMVKSGGYRVLLPLL 188
            .|.:..||..|.|:|  .:|:.:||:...::..::.      .||:     ::......|:..::
  Rat   125 HFTVNTLRSLGMGKR--TIEIKVQEEAEWLVMELKKTKGSPCDPKF-----IIGCAPCNVICSII 182

  Fly   189 F-NPFSANAHFYIVYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSIIPW-IRHIWPEWSGY 251
            | |.|.        |.:    ::...|::          |.::|.|::|...: :.:.:|....|
  Rat   183 FQNRFD--------YKD----KDFLSLIE----------NVNEYIKIVSTPAFQVFNAFPILLDY 225

  Fly   252 ---NKLNESNLF--VRQFFADFVDKYLDSYEEGVERNFMDVYIAEMRRGPG---YGFNRDQLIMG 308
               |....|..|  ::.:....:.::.:|.:....|:|:|.::.:..:..|   ..:.::.|.:.
  Rat   226 CPGNHKTHSKHFAAIKSYLLKKIKEHEESLDVSNPRDFIDYFLIQRCQENGNQQMNYTQEHLAIL 290

  Fly   309 LVDFSFPAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREG 373
            :.:..........:.|...:..||.||.:..:||.||.:|:|..|.|.:.||.::|:|.|.|.|.
  Rat   291 VTNLFIGGTETSSLTLRFALLLLMKYPHITDKVQEEIGQVIGRHRSPCMLDRIHMPYTNAMIHEV 355

  Fly   374 LRIETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLC 438
            .|...|.|:.:.|:...||:...|.|||.|.|:.||.:...|::.:.:||.|.|..|||.:|..
  Rat   356 QRYIDLAPNGLLHEVTCDTKFRDYFIPKGTAVLTSLTSVLHDSKEFPNPEMFDPGHFLDENGNF- 419

  Fly   439 LKLDVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDF--VLGPNDRLPDLSQNLNGLIISPPD 501
            .|.|..:||.||||.|.||..|...|||...|:.|:|..  :..|.|  .|::...:.....||.
  Rat   420 KKSDYFMPFSAGKRKCVGEGLASMELFLFLTTILQNFKLKSLSDPKD--IDINSIRSEFSSIPPT 482

  Fly   502 FWL 504
            |.|
  Rat   483 FQL 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	130/493 (26%)
Cyp2c12	NP_113760.2	CYP2C-like	61..485	CDD:410758	119/459 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000