Protein Alignment Cyp304a1 and Cyp2d3

DIOPT Version :10

• Sequence 1: NP_731751.1
• Gene: Cyp304a1 / 41586
• FlyBaseID: FBgn0038095
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_775116.1
• Gene: Cyp2d3 / 24303
• RGDID: 2472
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 497
• Identity: 140/497 - (28%)
• Similarity: 232/497 - (46%)
• Gaps: 54/497 - (10%)

  Fly    27 SGFPPGPPKIPLFGSYLFMLIINFKY-LHKAALTLSRWYKSDIIGLHVGPFPVAVVHSADGVREI 90
            |.:||||...|:.|:.|.:.:.|..| ::|    |...| .|:..|.:|..||.|::....|:|:
  Rat    34 SRYPPGPVPWPVLGNLLQVDLCNMPYSMYK----LQNRY-GDVFSLQMGWKPVVVINGLKAVQEL 93

  Fly    91 L---NNQVFDGRPQLFVAAMRDPGQDVRGIFFQD-GPLWKEQRRFILRYLRDFGFGRRFDQLELV 151
            |   .....| ||::.:......|...:|:.... ||.|:|||||.:..||:||.|::  .||..
  Rat    94 LVTCGEDTAD-RPEMPIFQHIGYGHKAKGVVLAPYGPEWREQRRFSVSTLRNFGVGKK--SLEQW 155

  Fly   152 IQEQLNDMLDLIRNGPKYPHEHEMVKSGGYRVLLP-LLFNPFSANAHFYIVYNECLSREEMG--- 212
            :.::.:.:.|.:           ..::|  |.|.| .|.|....|....::|   ..|.:.|
  Rat   156 VTDEASHLCDAL-----------TAEAG--RPLDPYTLLNKAVCNVIASLIY---ARRFDYGDPD 204

  Fly   213 --KLVKLCQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSGYNKLNESNLFVRQFFADFVDKYLDS 275
              |::|:.:         :..|:...:.|.:.:::|.......|.:.....::.|...||..:..
  Rat   205 FIKVLKILK---------ESMGEQTGLFPEVLNMFPVLLRIPGLADKVFPGQKTFLTMVDNLVTE 260

  Fly   276 YEEGVE-----RNFMDVYIAEMRR---GPGYGFNRDQLIMGLVDFSFPAFTAIGVQLSLLVQYLM 332
            :::..:     |:..|.::||:.:   .|...||...|.:.:.|..........:.|:..:..::
  Rat   261 HKKTWDPDQPPRDLTDAFLAEIEKAKGNPESSFNDANLRLVVNDLFGAGMVTTSITLTWALLLMI 325

  Fly   333 LYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLVPSDVPHKALEDTELLGY 397
            |:|.|..|||.|||||:|..|.|.:.|:.::|||.|.|.|..|...:||.::|||...|.|:.|:
  Rat   326 LHPDVQCRVQQEIDEVIGQVRHPEMADQAHMPFTNAVIHEVQRFADIVPMNLPHKTSRDIEVQGF 390

  Fly   398 RIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSLPFGAGKRLCAGETFARN 462
            .|||.|.::|:|.:...|..:|..|.:|.||.||||.|.. :|.:..:||.||:|.|.||..||.
  Rat   391 LIPKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGNF-VKHEAFMPFSAGRRACLGEPLARM 454

  Fly   463 MLFLVTATMCQHFDFVLGPNDRLPDLSQNLNGLIISPPDFWL 504
            .|||....:.|.|.|.:......|. ...:...::||..:.|
  Rat   455 ELFLFFTCLLQRFSFSVPTGQPRPS-DYGVFAFLLSPSPYQL 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	CYP15A1-like	66..504	CDD:410744	126/455 (28%)
Cyp2d3	NP_775116.1	CYP2D	68..495	CDD:410756	127/457 (28%)