Protein Alignment Cyp304a1 and Cyp2j12

DIOPT Version :10

• Sequence 1: NP_731751.1
• Gene: Cyp304a1 / 41586
• FlyBaseID: FBgn0038095
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001093652.1
• Gene: Cyp2j12 / 242546
• MGIID: 3717097
• Length: 502
• Species: Mus musculus
• Alignment Length: 531
• Identity: 151/531 - (28%)
• Similarity: 246/531 - (46%)
• Gaps: 76/531 - (14%)

  Fly     7 LTICAAVFLCLSYRYAVGRPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYK--SDII 69
            |.:.|..|:.|::.....||..:||||.::|..|: ||.|     .|.:..:.:.::.|  .::.
Mouse    21 LVLAAVTFMLLAHYLKTQRPKNYPPGPWRLPFVGN-LFQL-----DLEQPHVVIQQFVKKYGNLT 79

  Fly    70 GLHVGPFPVAVVHSADGVREILNN--QVFDGRPQLFVAAMRDPGQDVRGIFFQDGPLWKEQRRFI 132
            .|..|..|..::.....::|:..|  |.|..||   :..:|....:..|:...:|..|||||||.
Mouse    80 SLDFGNIPSVIITGLPLIKEVFTNMEQNFLNRP---ITPIRKRVFNNNGLIISNGQTWKEQRRFA 141

  Fly   133 LRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHE-HEMVKSGGYRVLLPLLFNP-FS-A 194
            |..|::||.|::  .||..||::.:.:::.|......|.: |..:.|....::....|.. |. .
Mouse   142 LMTLKNFGLGKK--SLEQRIQKEADCLVEAIGEEKGQPFDPHFKINSAVSNIICTFAFGERFEYE 204

  Fly   195 NAHFYIVYN-----ECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSIIPWI----RHIWPEWSG 250
            ::||:.:..     .||....|      ||:          |....|||.::    :.:...|
Mouse   205 DSHFHELLRLLDEATCLEASMM------CQL----------YNVFPSIIQYVPGSHQTVLRNW-- 251

  Fly   251 YNKLNESNLFVRQFFADFVDKYLDSYEEGVERNFMDVYIAEMRRGPGYG------FNRDQLIMGL 309
             .||   .||:.|    .::.:...:.....|:|:|.::.||.:   ||      ||.:.||...
Mouse   252 -EKL---KLFIYQ----MMESHRKDWNPDEPRDFIDAFLTEMSK---YGDKTTTSFNEENLINST 305

  Fly   310 VDFSFPAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGL 374
            :|..|.........|...:.|:...|.|..:|.:|||.|:|.||.|:.:||.::|:|.|.|.|.|
Mouse   306 LDLFFAGSETTTNTLRWALLYITTNPEVQEKVHSEIDRVIGHGRQPSTDDRDSMPYTNAVIHEVL 370

  Fly   375 RIETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCL 439
            |:..::|.:||.:...|:.|.|:.:||.|:|:.:|.|.|.|.:.|:.|..|.||.||: :|:. .
Mouse   371 RMGNILPMNVPREVTADSTLAGFHLPKGTMVLTNLTALHRDPKEWATPNTFNPEHFLE-NGQF-K 433

  Fly   440 KLDVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDFVLGPNDRLPDLSQNL-----NGLIISP 499
            |.:..|||..|||.|.||..||:.||:....:.|.|.|       .|.:::.|     |||.:||
Mouse   434 KRESFLPFSLGKRACPGEQLARSELFIFFTALMQKFTF-------KPPINEKLSLKFRNGLTLSP 491

  Fly   500 PDFWLQLQDRH 510
            ....:....||
Mouse   492 VSHCICAVPRH 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	CYP15A1-like	66..504	CDD:410744	132/462 (29%)
Cyp2j12	NP_001093652.1	cytochrome_P450	75..496	CDD:477761	132/463 (29%)