Protein Alignment Cyp304a1 and Cyp2a22

DIOPT Version :10

• Sequence 1: NP_731751.1
• Gene: Cyp304a1 / 41586
• FlyBaseID: FBgn0038095
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001094937.1
• Gene: Cyp2a22 / 233005
• MGIID: 3648316
• Length: 492
• Species: Mus musculus
• Alignment Length: 514
• Identity: 141/514 - (27%)
• Similarity: 233/514 - (45%)
• Gaps: 65/514 - (12%)

  Fly     1 MITETLLTICAAVFLCLSYRYAVGRP---SGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSR 62
            |:...||.:....||.:....:|.:.   ...||||..:|..|:|   |.:|.|.::.:...|..
Mouse     1 MLGSGLLLVAILAFLSVMVLVSVWQQKIRGKLPPGPIPLPFIGNY---LQLNRKDVYSSITQLQE 62

  Fly    63 WYKSDIIGLHVGPFPVAVVHSADGVREIL--NNQVFDGRPQ------LFVAAMRDPGQDVRGIFF 119
            .| ..:..:|:||..|.|::..|.|:|.|  |.:.|.||.:      ||..         .|:.|
Mouse    63 HY-GPVFTIHLGPRRVVVLYGYDAVKEALEDNAEEFSGRGEQATFNTLFKG---------YGVTF 117

  Fly   120 QDGPLWKEQRRFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHEMVKSGGYRVL 184
            .:|...|:.|||.:..|:|||.|:|  .:|..|||:...::.:::.....|.:..|       .|
Mouse   118 SNGERAKQLRRFSIATLKDFGLGKR--GMEERIQEEAGCLIKMLQGTCGAPIDPTM-------YL 173

  Fly   185 LPLLFNPFSANAHFYIVYNECLSREEMGKLVKLCQMGIQFQRNA--------DDYGKMLSIIPWI 241
            ...:.|..|:     ||:.:..:.|:. :.:.|.||..|..:.|        |.:..::..:|
Mouse   174 SKTVSNVISS-----IVFGDRFNYEDK-EFLSLLQMMSQMNQFAASPTGQLYDMFHSVMKYLP-- 230

  Fly   242 RHIWPEWSGYNKLNESNLFVRQFFADFVDKYLDSYEEGVERNFMDVYIAEMRRGPGYGFNRDQLI 306
               .|:    .::.:.:..:..|....|.....:.:....|.|:|.::..|::..  .||.:..:
Mouse   231 ---GPQ----QQIIKDSHKLEDFMIQKVKHNHSTLDPNSPRGFIDSFLIHMQKEK--NFNSEFHM 286

  Fly   307 MGLVDFSFPAFTAIGVQLSLLVQY----LMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTE 367
            ..||..|...|.|....:|.|::|    ||.:|.|..:|..|||.|:|..|.|..||...:|:|:
Mouse   287 KNLVMTSLNLFFAGSETVSSLLRYGFLLLMKHPDVEAKVHEEIDRVIGRNRQPQYEDHMKMPYTQ 351

  Fly   368 ATIREGLRIETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLD 432
            |.|.|..|.....|..:|.:..:||...|:.:||.|.|.|.:.:...|.:.:|.|:.|.|:.|||
Mouse   352 AVIHEIQRFSNFAPLGIPRRITKDTSFRGFFLPKGTDVFPIMGSLMIDPKFFSSPKDFNPQHFLD 416

  Fly   433 ADGKLCLKLDVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDFVLGPNDRLPDLSQN 491
            ..|:| .|:...|||..|||.|.|.:..:..|||...|:.|:|.|.. |. :|.|::::
Mouse   417 DKGQL-KKIPAFLPFSIGKRSCLGYSLGKMQLFLFFTTILQNFRFKF-PR-KLEDINES 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	CYP15A1-like	66..504	CDD:410744	123/446 (28%)
Cyp2a22	NP_001094937.1	CYP2A	64..487	CDD:410761	124/448 (28%)