Protein Alignment Cyp304a1 and Cyp2d4

DIOPT Version :10

• Sequence 1: NP_731751.1
• Gene: Cyp304a1 / 41586
• FlyBaseID: FBgn0038095
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_612524.1
• Gene: Cyp2d4 / 171522
• RGDID: 620640
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 498
• Identity: 139/498 - (27%)
• Similarity: 219/498 - (43%)
• Gaps: 56/498 - (11%)

  Fly    27 SGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYKSDIIGLHVGPFPVAVVHSADGVREIL 91
            |.:||||...|:.|:   :|.|:|:.: .|.....|....|:..|.:....|.|::....:||.|
  Rat    34 SRYPPGPVPWPVLGN---LLQIDFQNM-PAGFQKLRCRFGDLFSLQLAFESVVVLNGLPALREAL 94

  Fly    92 NNQVFD--GRPQLFVAAMRDPGQDVRGIFF-QDGPLWKEQRRFILRYLRDFGFGRRFDQLELVIQ 153
            .....|  .||.|........|...:|:.. :.||.|::||||.:...|.||.|::  .||..:.
  Rat    95 VKYSEDTADRPPLHFNDQSGFGPRSQGVVLARYGPAWRQQRRFSVSTFRHFGLGKK--SLEQWVT 157

  Fly   154 EQLNDMLDLIRNGPKYPHE-HEMVKSGGYRVLLPLLFN-PFSANAHFYIVYNECLS---REEMGK 213
            |:...:.....:...:|.. :.::......|:..|||. .|..|...:|...:.|.   .||.|.
  Rat   158 EEARCLCAAFADHSGFPFSPNTLLDKAVCNVIASLLFACRFEYNDPRFIRLLDLLKDTLEEESGF 222

  Fly   214 LVKLCQMGIQFQRNADDYGKMLSIIPWIRHI----WPEWSGYNKLNESNLFVRQFFADFVDKYLD 274
            |..|                 |::.|.:.||    ...:||           ::.|...:|:.|.
  Rat   223 LPML-----------------LNVFPMLLHIPGLLGKVFSG-----------KKAFVAMLDELLT 259

  Fly   275 SYEEGVE-----RNFMDVYIAEMRR---GPGYGFNRDQLIMGLVDFSFPAFTAIGVQLSLLVQYL 331
            .::...:     |:..|.::||:.:   .|...||.:.|.:.:.|............|:..:.::
  Rat   260 EHKVTWDPAQPPRDLTDAFLAEVEKAKGNPESSFNDENLRVVVADLFMAGMVTTSTTLTWALLFM 324

  Fly   332 MLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLVPSDVPHKALEDTELLG 396
            :|.|.|..|||.|||||:|..|.|.:.|:..:|||.|.|.|..|...::|..||||...|.|:.|
  Rat   325 ILRPDVQCRVQQEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADILPLGVPHKTSRDIEVQG 389

  Fly   397 YRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSLPFGAGKRLCAGETFAR 461
            :.|||.|.::.:|.:...|..:|..|.:|.||.||||.|.. :|.:..:||.||:|.|.||..||
  Rat   390 FLIPKGTTLIINLSSVLKDETVWEKPLRFHPEHFLDAQGNF-VKHEAFMPFSAGRRACLGEPLAR 453

  Fly   462 NMLFLVTATMCQHFDFVLGPNDRLPDLSQNLNGLIISPPDFWL 504
            ..|||....:.|.|.|.:......|. :..:.|.:.:|..:.|
  Rat   454 MELFLFFTCLLQRFSFSVPAGQPRPS-NYGVFGALTTPRPYQL 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	CYP15A1-like	66..504	CDD:410744	126/457 (28%)
Cyp2d4	NP_612524.1	CYP2D	68..495	CDD:410756	126/458 (28%)