DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp2d4

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_612524.1	Gene:	Cyp2d4 / 171522	RGDID:	620640	Length:	500	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	139/498 - (27%)
Similarity:	219/498 - (43%)	Gaps:	56/498 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYKSDIIGLHVGPFPVAVVHSADGVREIL 91
            |.:||||...|:.|:   :|.|:|:.: .|.....|....|:..|.:....|.|::....:||.|
  Rat    34 SRYPPGPVPWPVLGN---LLQIDFQNM-PAGFQKLRCRFGDLFSLQLAFESVVVLNGLPALREAL 94

  Fly    92 NNQVFD--GRPQLFVAAMRDPGQDVRGIFF-QDGPLWKEQRRFILRYLRDFGFGRRFDQLELVIQ 153
            .....|  .||.|........|...:|:.. :.||.|::||||.:...|.||.|::  .||..:.
  Rat    95 VKYSEDTADRPPLHFNDQSGFGPRSQGVVLARYGPAWRQQRRFSVSTFRHFGLGKK--SLEQWVT 157

  Fly   154 EQLNDMLDLIRNGPKYPHE-HEMVKSGGYRVLLPLLFN-PFSANAHFYIVYNECLS---REEMGK 213
            |:...:.....:...:|.. :.::......|:..|||. .|..|...:|...:.|.   .||.|.
  Rat   158 EEARCLCAAFADHSGFPFSPNTLLDKAVCNVIASLLFACRFEYNDPRFIRLLDLLKDTLEEESGF 222

  Fly   214 LVKLCQMGIQFQRNADDYGKMLSIIPWIRHI----WPEWSGYNKLNESNLFVRQFFADFVDKYLD 274
            |..|                 |::.|.:.||    ...:||           ::.|...:|:.|.
  Rat   223 LPML-----------------LNVFPMLLHIPGLLGKVFSG-----------KKAFVAMLDELLT 259

  Fly   275 SYEEGVE-----RNFMDVYIAEMRR---GPGYGFNRDQLIMGLVDFSFPAFTAIGVQLSLLVQYL 331
            .::...:     |:..|.::||:.:   .|...||.:.|.:.:.|............|:..:.::
  Rat   260 EHKVTWDPAQPPRDLTDAFLAEVEKAKGNPESSFNDENLRVVVADLFMAGMVTTSTTLTWALLFM 324

  Fly   332 MLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLVPSDVPHKALEDTELLG 396
            :|.|.|..|||.|||||:|..|.|.:.|:..:|||.|.|.|..|...::|..||||...|.|:.|
  Rat   325 ILRPDVQCRVQQEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADILPLGVPHKTSRDIEVQG 389

  Fly   397 YRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSLPFGAGKRLCAGETFAR 461
            :.|||.|.::.:|.:...|..:|..|.:|.||.||||.|.. :|.:..:||.||:|.|.||..||
  Rat   390 FLIPKGTTLIINLSSVLKDETVWEKPLRFHPEHFLDAQGNF-VKHEAFMPFSAGRRACLGEPLAR 453

  Fly   462 NMLFLVTATMCQHFDFVLGPNDRLPDLSQNLNGLIISPPDFWL 504
            ..|||....:.|.|.|.:......|. :..:.|.:.:|..:.|
  Rat   454 MELFLFFTCLLQRFSFSVPAGQPRPS-NYGVFGALTTPRPYQL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	137/493 (28%)
Cyp2d4	NP_612524.1	p450	37..496	CDD:278495	138/495 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910