Protein Alignment Cyp304a1 and Cyp2c22

DIOPT Version :10

• Sequence 1: NP_731751.1
• Gene: Cyp304a1 / 41586
• FlyBaseID: FBgn0038095
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_612521.2
• Gene: Cyp2c22 / 171518
• RGDID: 620368
• Length: 489
• Species: Rattus norvegicus
• Alignment Length: 516
• Identity: 141/516 - (27%)
• Similarity: 246/516 - (47%)
• Gaps: 70/516 - (13%)

  Fly    13 VFLCLSYRYAVGRPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYKSDIIGLHVGPFP 77
            |||.|..::.|.|.  .||||..:|:||:   :|.:..|.:.|:...|::.| ..:..:::|..|
  Rat    15 VFLFLWNQHHVRRK--LPPGPTPLPIFGN---ILQVGVKNISKSMCMLAKEY-GPVFTMYLGMKP 73

  Fly    78 VAVVHSADGVREILNNQVFDGRPQLFVAAMRDPGQDVRGIFFQDGPLWKEQRRFILRYLRDFGFG 142
            ..|::..:.::|.|.::..:...::..:.:....|.: ||.|.:|.:||:.|||.|..||..|.|
  Rat    74 TVVLYGYEVLKEALIDRGEEFSDKMHSSMLSKVSQGL-GIVFSNGEIWKQTRRFSLMVLRSMGMG 137

  Fly   143 RRFDQLELVIQEQLNDMLDLIR--NG----PKYPHEHEMVKSGGYRVLLPLLFNPFSANAHFYIV 201
            :|  .:|..|||::..:|:.:|  ||    |.:     ::......|:..::|.      |.:..
  Rat   138 KR--TIENRIQEEVVYLLEALRKTNGSPCDPSF-----LLACVPCNVISSVIFQ------HRFDY 189

  Fly   202 YNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSII--PW--------IRHIWPEWSGYNKLNE 256
            .:|                  :||:..:::...:.|:  ||        :.:..|  ..:||..:
  Rat   190 SDE------------------KFQKFIENFHTKIEILASPWAQLCSAYPVLYYLP--GIHNKFLK 234

  Fly   257 SNLFVRQFFADFVDKYLDSYEEGVERNFMDVYIAEM---RRGPGYGFNRDQLIMGLVDFSFPA-- 316
            .....::|....::::..|......::|:|.::.:|   :......|..|.||:.:.|. |.|
  Rat   235 DVTEQKKFILMEINRHRASLNLSNPQDFIDYFLIKMEKEKHNEKSEFTMDNLIVTIGDL-FGAGT 298

  Fly   317 -FTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLV 380
             .|:..::..||:  |:.||.|..::|.||..|:|..|.|.::||.::|:|:|.:.|..|....|
  Rat   299 ETTSSTIKYGLLL--LLKYPEVTAKIQEEITRVIGRHRRPCMQDRNHMPYTDAVLHEIQRYIDFV 361

  Fly   381 PSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSL 445
            |..:|.|..:|.|..||.|||.|.|:..|.:...|.:.:.:||:|.|..|||..|.. .|.|..:
  Rat   362 PIPLPRKTTQDVEFRGYHIPKGTSVMACLTSALHDDKEFPNPEKFDPGHFLDEKGNF-KKSDYFM 425

  Fly   446 PFGAGKRLCAGETFARNMLFLVTATMCQHFDF--VLGPNDRLPDLSQNLNGLIISPPDFWL 504
            .|.||:|.|.||..||..:||:..::.|||..  ::.|.|  .|.:....||:..||.|.|
  Rat   426 AFSAGRRACIGEGLARMEMFLILTSILQHFTLKPLVNPED--IDTTPVQPGLLSVPPPFEL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	CYP15A1-like	66..504	CDD:410744	122/461 (26%)
Cyp2c22	NP_612521.2	CYP2C-like	61..484	CDD:410758	123/463 (27%)