DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp2t1

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_599196.2	Gene:	Cyp2t1 / 171380	RGDID:	620086	Length:	497	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	146/529 - (27%)
Similarity:	234/529 - (44%)	Gaps:	52/529 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIT--ETLLTICAAVFLCLSYRYAVGR-----PSGFPPGPPKIPLFGSYLFMLIINFKYLHKAAL 58
            |:|  .|||.:.....:.:|:.:...:     ....||||..:||.|:   :|.:...:|.:..:
  Rat     1 MVTCEATLLLLLILTLMLMSWGWLAHQARARMQKDLPPGPAPLPLLGN---LLQLQSGHLDRVLM 62

  Fly    59 TL-SRWYKSDIIGLHVGPFPVAVVHSADGVRE--ILNNQVFDGRPQLFVAAMRDPGQDVRGIFFQ 120
            .| |||  ..:..:.:||.|..|:.....:|:  :|....|.||..:.|......|   .||.|.
  Rat    63 ELSSRW--GPVFTVWLGPRPAVVLSGYAALRDALVLQADAFSGRGSMAVFERFTHG---NGIVFS 122

  Fly   121 DGPLWKEQRRFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHE-HEMVKSGGYRVL 184
            :||.|:..|.|.|..|::||.|.  ..:|..|.|:...:||..:.....|.: ..::.:....|:
  Rat   123 NGPRWRTLRNFALGALKEFGVGT--STIEERILEETACVLDEFQATMGAPFDPRRLLDNAVSNVI 185

  Fly   185 LPLLFNPFSANAHFYIVYNECLSREEMGKLVKLC--QMGIQFQRNADDYGKMLSIIPWIRHIWPE 247
            ..::|..         .||  ....|..:|:.|.  ...|...|..:.|....|.:.||.  .|.
  Rat   186 CTVVFGK---------RYN--YGDPEFLRLLDLFSDNFRIMSSRWGETYNMFPSFMDWIP--GPH 237

  Fly   248 WSGYNKLNESNLFVRQFFADFVDKYLDSYEEGVERNFMDVYIAEM---RRGPGYGFNRDQLIMGL 309
            ...:....|..||:    ::.:..:..|.:.|..|:|:|.::.:|   .:.|...|..:.|:|..
  Rat   238 HRIFKNFQELRLFI----SEQIQWHRQSRQTGEPRDFIDCFLEQMDKEHQDPESHFQDETLVMTT 298

  Fly   310 VDFSF--PAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIRE 372
            .:..|  ...|:..::..||:  ::.||.|..:||.|:|..||..|.|:|.||.:||:|.|.:.|
  Rat   299 HNLFFGGTETTSTTLRYGLLI--MLKYPEVAAKVQEELDATVGRTRAPSLADRAHLPYTNAVLHE 361

  Fly   373 GLRIETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKL 437
            ..|..:::|..:|...:.|..|..:.:.|.|.|:|.|.:.|.|...:.||:.|.|..|||..|:.
  Rat   362 IQRFISVLPLGLPRALIRDVNLRNHFLHKGTFVIPLLVSAHRDPTQFKDPDHFNPTNFLDDQGEF 426

  Fly   438 CLKLDVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDF--VLGPNDRLPDLSQNLNGLIISPP 500
             ...|..:||..|||:|.|...||:.:||....:.|.|..  |..|.|  .||:....||...||
  Rat   427 -QNNDAFMPFAPGKRMCLGAGLARSEIFLFLTAILQKFSLLPVGSPAD--IDLTPQCTGLGNVPP 488

  Fly   501 DFWLQLQDR 509
            .|.|:|..|
  Rat   489 AFQLRLVAR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	137/486 (28%)
Cyp2t1	NP_599196.2	cytochrome_P450	68..492	CDD:425388	125/452 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000