DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and CYP2J2

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_000766.2	Gene:	CYP2J2 / 1573	HGNCID:	2634	Length:	502	Species:	Homo sapiens

Alignment Length:	529	Identity:	151/529 - (28%)
Similarity:	238/529 - (44%)	Gaps:	88/529 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MITETLLTICAAVFLCLSYRYAVGRPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYK 65
            ::..|:..:.||.||      ...||..:||||.::|..|::   .:::|:..|.......:.|
Human    21 LLLGTVAFLLAADFL------KRRRPKNYPPGPWRLPFLGNF---FLVDFEQSHLEVQLFVKKY- 75

  Fly    66 SDIIGLHVGPFPVAVVHSADGVREIL--NNQVFDGRPQLFVAAMRDPGQDVRGIFFQDGPLWKEQ 128
            .::..|.:|.....::.....::|.|  .:|.|..||   |..||:......|:....|..||||
Human    76 GNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRP---VTPMREHIFKKNGLIMSSGQAWKEQ 137

  Fly   129 RRFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIR--NG-PKYPH-----------------EH 173
            |||.|..||:||.|::  .||..|||:...:.:.|:  || |..||                 |.
Human   138 RRFTLTALRNFGLGKK--SLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGER 200

  Fly   174 EMVKSGGYRVLLPLLFNPFSANAHFYIVYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSII 238
            ...:...::.||.||..         :.|.|.         .|.||              :.::.
Human   201 FEYQDSWFQQLLKLLDE---------VTYLEA---------SKTCQ--------------LYNVF 233

  Fly   239 PWIRHIWPE-----WSGYNKLNESNLFVRQFFADFVDKYLDSYEEGVERNFMDVYIAEMRR---G 295
            |||....|.     :|.:.||       :.|.:..:||:...:.....|:|:|.|:.||.:   .
Human   234 PWIMKFLPGPHQTLFSNWKKL-------KLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGN 291

  Fly   296 PGYGFNRDQLIMGLVDFSFPAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDR 360
            |...|:.:.||...:|..|.........|...:.|:.|||.:..:||.|||.|:|.|:.|:...|
Human   292 PTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAAR 356

  Fly   361 KNLPFTEATIREGLRIETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQF 425
            :::|:|.|.|.|..|:..::|.:||.:...||.|.||.:||.|:::.:|.|.|.|...|:.|:.|
Human   357 ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTF 421

  Fly   426 RPERFLDADGKLCLKLDVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDFVLGPNDRLPDLSQ 490
            .|:.||: :|:. .|.:..:||..|||.|.||..||..||:...::.|.|.| ..||:....|..
Human   422 NPDHFLE-NGQF-KKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTF-RPPNNEKLSLKF 483

  Fly   491 NLNGLIISP 499
            .: |:.|||
Human   484 RM-GITISP 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	144/500 (29%)
CYP2J2	NP_000766.2	p450	44..497	CDD:365848	144/500 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910