DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and CYP2D6

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_000097.3	Gene:	CYP2D6 / 1565	HGNCID:	2625	Length:	497	Species:	Homo sapiens

Alignment Length:	524	Identity:	152/524 - (29%)
Similarity:	236/524 - (45%)	Gaps:	66/524 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LTICAAVFLCL------SYRYAVGRPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYK 65
            |.:..|:||.|      ..|:|    :.:||||..:|..|:.|.:...|..|...   .|.|.:
Human     9 LAVIVAIFLLLVDLMHRRQRWA----ARYPPGPLPLPGLGNLLHVDFQNTPYCFD---QLRRRF- 65

  Fly    66 SDIIGLHVGPFPVAVVHSADGVREILNNQVFD--GRPQLFVAAMRDPGQDVRGIFF-QDGPLWKE 127
            .|:..|.:...||.|::....|||.|.....|  .||.:.:..:...|...:|:|. :.||.|:|
Human    66 GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWRE 130

  Fly   128 QRRFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHEMVKSGGYRVLLPLLFNPF 192
            ||||.:..||:.|.|::  .||..:.|:...:.....|     |.....:..|       |.:..
Human   131 QRRFSVSTLRNLGLGKK--SLEQWVTEEAACLCAAFAN-----HSGRPFRPNG-------LLDKA 181

  Fly   193 SANAHFYIVYNECLSREEMG-----KLVKLCQMGIQ----FQRNADDYGKMLSIIPWIRHIWPEW 248
            .:|.   |....|..|.|..     :|:.|.|.|::    |.|      ::|:.:|.:.|| |..
Human   182 VSNV---IASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLR------EVLNAVPVLLHI-PAL 236

  Fly   249 SGYNKLNESNLFVRQFFADFVDKYLDSYEEGVE-----RNFMDVYIAEMRR---GPGYGFNRDQL 305
            :| ..|.....|:.|     :|:.|..:....:     |:..:.::|||.:   .|...||.:.|
Human   237 AG-KVLRFQKAFLTQ-----LDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENL 295

  Fly   306 IMGLVDFSFPAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATI 370
            .:.:.|............|:..:..::|:|.|.||||.|||:|:|..|.|.:.|:.::|:|.|.|
Human   296 RIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI 360

  Fly   371 REGLRIETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADG 435
            .|..|...:||..|.|....|.|:.|:||||.|.::.:|.:...|..:|..|.:|.||.||||.|
Human   361 HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG 425

  Fly   436 KLCLKLDVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDFVLGPNDRLPDLSQNLNGLIISPP 500
            .. :|.:..|||.||:|.|.||..||..|||...::.|||.|.:......|. ...:...::||.
Human   426 HF-VKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPS-HHGVFAFLVSPS 488

  Fly   501 DFWL 504
            .:.|
Human   489 PYEL 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	144/493 (29%)
CYP2D6	NP_000097.3	p450	58..493	CDD:278495	136/471 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910