Protein Alignment Cyp304a1 and CYP2D7

DIOPT Version :10

• Sequence 1: NP_731751.1
• Gene: Cyp304a1 / 41586
• FlyBaseID: FBgn0038095
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001335315.1
• Gene: CYP2D7 / 1564
• HGNCID: 2624
• Length: 516
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 149/549 - (27%)
• Similarity: 234/549 - (42%)
• Gaps: 104/549 - (18%)

  Fly     7 LTICAAVFLCL------SYRYAVGRPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYK 65
            |.:..|:||.|      ..|:|    :.:||||..:|..|:.|.:...|..|...   .|.|.:
Human     9 LAMIVAIFLLLVDLMHRHQRWA----ARYPPGPLPLPGLGNLLHVDFQNTPYCFD---QLRRRF- 65

  Fly    66 SDIIGLHVGPFPVAVVHSADGVREILNNQVFD--GRPQLFVAAMRDPGQDVRGIFF-QDGPLWKE 127
            .|:..|.:...||.|::....|||.:..:..|  .||...:..:...|...:|:.. :.||.|:|
Human    66 GDVFSLQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPAPIYQVLGFGPRSQGVILSRYGPAWRE 130

  Fly   128 QRRFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHEMVKSGGYRVLLPLLFNPF 192
            ||||.:..||:.|.|::  .||..:.|:...:.....:           ::|          .||
Human   131 QRRFSVSTLRNLGLGKK--SLEQWVTEEAACLCAAFAD-----------QAG----------RPF 172

  Fly   193 SANAHF------YIVYNECLSREEMG-----KLVKLCQMGIQ----FQRNADDYGKMLSIIPWIR 242
            ..|...      .|....|..|.|..     :|:.|.|.|::    |.|      ::|:.:|.:.
Human   173 RPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLR------EVLNAVPVLP 231

  Fly   243 HIWPEWSGYNKLNESNLFVRQFFADFVDKYLDSYEEGVE-----RNFMDVYIAEMRR---GPGYG 299
            || |..:| ..|.....|:.|     :|:.|..:....:     |:..:.::|:..:   .|...
Human   232 HI-PALAG-KVLRFQKAFLTQ-----LDELLTEHRMTWDPAQPPRDLTEAFLAKKEKAKGSPESS 289

  Fly   300 FNRDQL--------IMGLVDFSFPAFTAIGVQLSLLVQYLMLY----------PAVLR-----RV 341
            ||.:.|        :.|:|..|    |.:...|.|::.:|.:.          |.|..     ||
Human   290 FNDENLRIVVGNLFLAGMVTTS----TTLAWGLLLMILHLDVQRGRRVSPGCSPIVGTHVCPVRV 350

  Fly   342 QNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLVPSDVPHKALEDTELLGYRIPKDTIVV 406
            |.|||:|:|..|.|.:.|:.::|.|.|.|.|......:||..|.|....|.|:.|:||||.|.::
Human   351 QQEIDDVIGQVRRPEMGDQAHMPCTTAVIHEVQHFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLI 415

  Fly   407 PSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSLPFGAGKRLCAGETFARNMLFLVTATM 471
            .:|.:...|..:|..|.:|.||.||||.|.. :|.:..|||.||:|.|.||..||..|||...::
Human   416 TNLSSVLKDEAVWKKPFRFHPEHFLDAQGHF-VKPEAFLPFSAGRRACLGEPLARMELFLFFTSL 479

  Fly   472 CQHFDFVLGPNDRLPDLSQNLNGLIISPP 500
            .|||.|.:......|..|:.::.|:...|
Human   480 LQHFSFSVAAGQPRPSHSRVVSFLVTPSP 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	CYP15A1-like	66..504	CDD:410744	131/484 (27%)
CYP2D7	NP_001335315.1	CYP2D	65..511	CDD:410756	131/486 (27%)