Protein Alignment Cyp304a1 and CYP2C19

DIOPT Version :9

• Sequence 1: NP_731751.1
• Gene: Cyp304a1 / 41586
• FlyBaseID: FBgn0038095
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_000760.1
• Gene: CYP2C19 / 1557
• HGNCID: 2621
• Length: 490
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 143/516 - (27%)
• Similarity: 242/516 - (46%)
• Gaps: 53/516 - (10%)

  Fly     6 LLTICAAVFLCLS-YRYAVGRPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYKSDII 69
            :|.:|.:..|.|| :|.:.|| ...||||..:|:.|:   :|.|:.|.:.|:...||:.| ..:.
Human     6 VLVLCLSCLLLLSIWRQSSGR-GKLPPGPTPLPVIGN---ILQIDIKDVSKSLTNLSKIY-GPVF 65

  Fly    70 GLHVGPFPVAVVHSADGVREILNN--QVFDGRPQLFVAAMRDPGQDVRGIFFQDGPLWKEQRRFI 132
            .|:.|...:.|:|..:.|:|.|.:  :.|.||....:|...:.|   .||.|.:|..|||.|||.
Human    66 TLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRG---FGIVFSNGKRWKEIRRFS 127

  Fly   133 LRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHEMVKSGGYRVLLPLLFNPFSANAH 197
            |..||:||.|:|  .:|..:||:...:::.:|.....|.:...:            ......|..
Human   128 LMTLRNFGMGKR--SIEDRVQEEARCLVEELRKTKASPCDPTFI------------LGCAPCNVI 178

  Fly   198 FYIVYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSII--PWIR--HIWPEWSGY-----NK 253
            ..|::.:....::.           ||....:...:.:.|:  |||:  :.:|....|     ||
Human   179 CSIIFQKRFDYKDQ-----------QFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNK 232

  Fly   254 LNESNLFVRQFFADFVDKYLDSYEEGVERNFMDVYIAEM---RRGPGYGFNRDQLIMGLVDFSFP 315
            |.::..|:.....:.|.::.:|.:....|:|:|.::.:|   ::.....|..:.|::...|....
Human   233 LLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGA 297

  Fly   316 AFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLV 380
            ........|...:..|:.:|.|..:||.||:.|:|..|.|.::||.::|:|:|.:.|..|...|:
Human   298 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLI 362

  Fly   381 PSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSL 445
            |:.:||....|.:...|.|||.|.::.||.:...|.:.:.:||.|.|..|||..|.. .|.:..:
Human   363 PTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNF-KKSNYFM 426

  Fly   446 PFGAGKRLCAGETFARNMLFLVTATMCQHFDF--VLGPNDRLPDLSQNLNGLIISPPDFWL 504
            ||.||||:|.||..||..|||....:.|:|:.  ::.|.|.  |.:..:||....||.:.|
Human   427 PFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDL--DTTPVVNGFASVPPFYQL 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	134/489 (27%)
CYP2C19	NP_000760.1	p450	30..487	CDD:365848	135/491 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910