Protein Alignment Cyp304a1 and CYP1B1

DIOPT Version :10

• Sequence 1: NP_731751.1
• Gene: Cyp304a1 / 41586
• FlyBaseID: FBgn0038095
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_000095.2
• Gene: CYP1B1 / 1545
• HGNCID: 2597
• Length: 543
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 147/511 - (28%)
• Similarity: 226/511 - (44%)
• Gaps: 83/511 - (16%)

  Fly    30 PPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYKSDIIGLHVGPFPVAVVHSADGVREILNNQ 94
            ||||...||.|:...:    .:..|.:...|:|.| .|:..:.:|..|:.|::....:.:.|..|
Human    51 PPGPFAWPLIGNAAAV----GQAAHLSFARLARRY-GDVFQIRLGSCPIVVLNGERAIHQALVQQ 110

  Fly    95 --VFDGRPQLFVAAMRDPGQDVRGIFFQDGPLWKEQRRFILRYLRDFGFGR--RFDQ-LELVIQE 154
              .|..||......:...|:.:  .|......||.|||.....:|:| |.|  |..| ||..:..
Human   111 GSAFADRPAFASFRVVSGGRSM--AFGHYSEHWKVQRRAAHSMMRNF-FTRQPRSRQVLEGHVLS 172

  Fly   155 QLNDMLDLIRNGPKYPHEHEMVKSGGYRVLLPL----LFNPFSA------NAHFYIVYNECLS-R 208
            :..:::.|:..|.         ..|.:....||    :.|..||      .:|....:.|.|| .
Human   173 EARELVALLVRGS---------ADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHN 228

  Fly   209 EEMGKLVKLCQMGIQFQRNADDYGKMLSIIPW-------IRHIWPEWSGYNKLNESNLFVRQFFA 266
            ||.|:.|              ..|.::.::||       :|.::.|:...|: |.||..:.:|.
Human   229 EEFGRTV--------------GAGSLVDVMPWLQYFPNPVRTVFREFEQLNR-NFSNFILDKFL- 277

  Fly   267 DFVDKYLDSYEEG-VERNFMDVYI--AEMR-----RGPGYGFNRDQLIMGLVDFSFPAFTAIGVQ 323
                ::.:|...| ..|:.||.:|  ||.:     .|.|...:.:.:...:.|.    |.|....
Human   278 ----RHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDI----FGASQDT 334

  Fly   324 LSLLVQYLML----YPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLVPSDV 384
            ||..:|:|:|    ||.|..|||.|:|:|||..|||.:.|:.|||:..|.:.|.:|..:.||..:
Human   335 LSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTI 399

  Fly   385 PHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVS---LP 446
            ||....:|.:|||.|||||:|..:.::.:.|...|.:||.|.|.||||.||  .:..|::   :.
Human   400 PHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDG--LINKDLTSRVMI 462

  Fly   447 FGAGKRLCAGETFARNMLFLVTATMCQHFDFVLGPNDRLPDLSQNLNGLIISPPDF 502
            |..|||.|.||..::..|||..:.:....||...||:  |.......||.|.|..|
Human   463 FSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNE--PAKMNFSYGLTIKPKSF 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	CYP15A1-like	66..504	CDD:410744	136/475 (29%)
CYP1B1	NP_000095.2	CYP1B1-like	81..518	CDD:410768	137/477 (29%)