DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp2g1

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_038837.1	Gene:	Cyp2g1 / 13108	MGIID:	109612	Length:	494	Species:	Mus musculus

Alignment Length:	513	Identity:	141/513 - (27%)
Similarity:	234/513 - (45%)	Gaps:	49/513 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LTICAAVFLCLSYRYAVGRPSGFPPGPPKIPLFGSYLFMLI-INFKYLHKAALTLSRWYKSDIIG 70
            :.:|.:..|.|.......:....||||..||..|::|.:.. ..|:...|    |.:.|.| :..
Mouse    11 MALCLSCLLILIAWKRTSKGGKLPPGPTPIPFLGNFLQVRTDATFQSFQK----LQKKYGS-VFT 70

  Fly    71 LHVGPFPVAVVHSADGVREILNNQV--FDGRPQLFVAAMRDPGQDVRGIFFQDGPLWKEQRRFIL 133
            ::.||.||.|:...:.|:|.|.:|.  |.||.::........|.   |:...:|..||..|||.|
Mouse    71 VYFGPRPVVVLCGHEAVKEALVDQADDFSGRGEMPTLEKNFQGY---GLALSNGERWKILRRFSL 132

  Fly   134 RYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHEMVKSGGYRVLLPLLFNPFSANAHF 198
            ..||:||.|:|  .:|..|||:...:|:            |:.|..|..:...|..:...:|...
Mouse   133 TVLRNFGMGKR--SIEERIQEEAGYLLE------------ELHKVKGAPIDPTLYLSRTVSNVIC 183

  Fly   199 YIVYNECLSREE--MGKLVKL-----CQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSGYNKLNE 256
            .:|:.:....::  ...|:::     .:|...:.:..|.|.|::...|. ||.:.    ||.:.:
Mouse   184 SVVFGKRFDYQDQRFQSLMRMINESFVEMSKPWAQLYDMYWKVMQYFPG-RHNYL----YNLIED 243

  Fly   257 SNLFVRQFFADFVDKYLDSYEEGVERNFMDVYIAEM---RRGPGYGFNRDQLIMGLVDFSFPAFT 318
                ::.|.|..|.....|::....|:|:|.::.:|   :..|...||...|::..::..|....
Mouse   244 ----LKDFIASRVKINEASFDPSNPRDFIDCFLIKMHQDKSDPHTEFNLKNLVLTTLNLFFAGTE 304

  Fly   319 AIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLVPSD 383
            .:...|......|:.||.|..::..||::|:|..|.|.::||..:|:|:|.|.|..|:..:||..
Mouse   305 TVSSTLRYGFLLLLKYPEVEAKIHEEINQVIGTHRTPRVDDRAKMPYTDAVIHEIQRLTDIVPLG 369

  Fly   384 VPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSLPFG 448
            |||....||...||.:||.|.|.|...:...|.:.:..|:.|.|:.|||..|:. .|.|..:.|.
Mouse   370 VPHNVTRDTHFRGYLLPKGTDVYPLFGSVLKDPKYFRYPDAFYPQHFLDEQGRF-KKNDAFVVFS 433

  Fly   449 AGKRLCAGETFARNMLFLVTATMCQHFDF--VLGPNDRLPDLSQNLNGLIISPPDFWL 504
            :|||:|.||..||..|||...::.|.|..  ::.|.|  .|::..::|....||.:.|
Mouse   434 SGKRICVGEALARMELFLYFTSILQRFSLRSLVPPAD--IDIAHKISGFGNIPPVYEL 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	137/488 (28%)
Cyp2g1	NP_038837.1	p450	34..491	CDD:278495	138/490 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910