Protein Alignment Cyp304a1 and Cyp2d9

DIOPT Version :10

• Sequence 1: NP_731751.1
• Gene: Cyp304a1 / 41586
• FlyBaseID: FBgn0038095
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_034136.2
• Gene: Cyp2d9 / 13105
• MGIID: 88606
• Length: 504
• Species: Mus musculus
• Alignment Length: 496
• Identity: 139/496 - (28%)
• Similarity: 232/496 - (46%)
• Gaps: 52/496 - (10%)

  Fly    27 SGFPPGPPKIPLFGSYLFMLIINFKY-LHKAALTLSRWYKSDIIGLHVGPFPVAVVHSADGVREI 90
            |.:||||...|:.|:.|.:.:.|..| |:|    |...| .|:..|.:...|:.|::....::|:
Mouse    34 SRYPPGPVPWPVLGNLLQVDLGNMPYSLYK----LQNRY-GDVFSLQMAWKPMVVINGLKAMKEM 93

  Fly    91 L---NNQVFDGRP-QLFVAAMRDPGQDVRGIFFQD-GPLWKEQRRFILRYLRDFGFGRRFDQLEL 150
            |   .....|..| .:|......||.  :|:.... ||.|:|||||.:..||:||.|::  .||.
Mouse    94 LLTCGEDTADRPPVPIFEYLGVKPGS--QGVVLAPYGPEWREQRRFSVSTLRNFGLGKK--SLED 154

  Fly   151 VIQEQLNDMLDLIRNGPKYP-HEHEMVKSGGYRVLLPLLF-NPFSANAHFYIVYNECLSREEMGK 213
            .:.::.|.:.|........| :.:.|:......|:..|:| ..|.....|.|            :
Mouse   155 WVTKEANHLCDAFTAQAGQPINPNPMLNKSTCNVIASLIFARRFEYEDPFLI------------R 207

  Fly   214 LVKLCQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSGYNKLNESNLFVRQFFADFVDKYL----- 273
            ::|:.:..:.         ::..:||.:.:.:|......:|.:..|..::.|...:|..|
Mouse   208 MLKVLEQSLT---------EVSGLIPEVLNAFPILLRIPRLADKALQGQKSFIAILDNLLTENRT 263

  Fly   274 --DSYEEGVERNFMDVYIAEMRR---GPGYGFNRDQLIMGLVDFSFPAFTAIGVQLSLLVQYLML 333
              |..:  ..||..|.::||:.:   .|...||.:.|:|.:.|............||..:..::|
Mouse   264 TWDPVQ--APRNLTDAFLAEIEKAKGNPESSFNDENLLMVVRDLFGAGMLTTSTTLSWALMLMIL 326

  Fly   334 YPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLVPSDVPHKALEDTELLGYR 398
            :|.|.||||.|||||:|..|.|.:.|:.::|:|.|.|.|..|...:||.::|.....|.|:..:.
Mouse   327 HPDVQRRVQQEIDEVIGQVRHPEMADQAHMPYTNAVIHEVQRFGDIVPVNLPRITSHDIEVQDFL 391

  Fly   399 IPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSLPFGAGKRLCAGETFARNM 463
            |||.||::|::.:...|..:|..|.:|.||.||||.|.. :|.:..:||.||:|.|.||..||..
Mouse   392 IPKGTILLPNMSSMLKDESVWEKPLRFHPEHFLDAQGHF-VKPEAFMPFSAGRRSCLGEALARME 455

  Fly   464 LFLVTATMCQHFDFVLGPNDRLPDLSQNLNGLIISPPDFWL 504
            |||....:.|.|.|.: |:.:....:..:.|::::|..:.|
Mouse   456 LFLFFTCLLQRFSFSV-PDGQPQPSNSGVYGILVAPSPYQL 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	CYP15A1-like	66..504	CDD:410744	124/454 (27%)
Cyp2d9	NP_034136.2	CYP2D	68..495	CDD:410756	125/456 (27%)