DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp2b9

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_011248733.1	Gene:	Cyp2b9 / 13094	MGIID:	88600	Length:	517	Species:	Mus musculus

Alignment Length:	459	Identity:	137/459 - (29%)
Similarity:	217/459 - (47%)	Gaps:	65/459 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 DIIGLHVGPFPVAVVHSADGVREIL--NNQVFDGRPQLFVA--AMRDPGQDVRGIFFQDGPLWKE 127
            |:..:|:||.||.|:.....:||.|  :.:.|.||..:..|  .|:|     .||||..|..||.
Mouse    90 DVFTVHLGPRPVVVLCGTQTIREALVDHAEAFSGRGTIAAAQLVMQD-----YGIFFASGQRWKT 149

  Fly   128 QRRFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHEMVKSGGYRVLLPLLFNPF 192
            .|||.|..:::||.|:|  .:|..|:|:...:::            |:.|..|..:....||...
Mouse   150 LRRFSLATMKEFGMGKR--SVEERIKEEAQCLVE------------ELKKYQGVPLDPTFLFQCI 200

  Fly   193 SANAHFYIVYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSG------- 250
            :||....||:.|                  :|....|.:..:|:::..|..:...:||
Mouse   201 TANIICSIVFGE------------------RFDYTDDQFLHLLNLMYKIFSLLSSFSGQMFELFS 247

  Fly   251 ---------YNKLNESNLFVRQFFADFVDKYLDSYEEGVERNFMDVYIAEMRR---GPGYGFNRD 303
                     :.::.:....:..:.|..|:|:..:.:....|:::|.|:..|.:   .....|:..
Mouse   248 GFLKYFPGVHRQIVKKQQELLDYIAHSVEKHKATLDPSAPRDYIDTYLLRMEKEKSNHNTEFHHQ 312

  Fly   304 QLIMGLVDFSFPAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEA 368
            .|:|.::...|.........|...|..::.||.|..:||.|||:|:|..|||.|:||..:|:|:|
Mouse   313 NLMMSVLSLFFAGTETTSATLHYGVLLMLKYPHVTEKVQKEIDQVIGSHRLPTLDDRTKMPYTDA 377

  Fly   369 TIREGLRIETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDA 433
            .|.|..|...|||..:|||.::||...||.:||:|.|.|.|.:...|.:.:..|::|.||.||||
Mouse   378 VIHEIQRFSDLVPIGLPHKVIKDTLFRGYLLPKNTEVYPVLSSALHDPQYFEQPDKFNPEHFLDA 442

  Fly   434 DGKLCLKLDVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDFV--LGPNDRLPDLSQNLNGLI 496
            :|.| .|.:..|||..|||:|.||:.|||.||:...|:.|:|...  :.|.|  .||:...:|:.
Mouse   443 NGAL-KKCEAFLPFSTGKRICLGESIARNELFIFFTTILQNFSVASPVAPKD--IDLTPKESGIG 504

  Fly   497 ISPP 500
            ..||
Mouse   505 KIPP 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	137/459 (30%)
Cyp2b9	XP_011248733.1	p450	82..512	CDD:365848	137/459 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910