DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp2b19

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_031840.1	Gene:	Cyp2b19 / 13090	MGIID:	107303	Length:	492	Species:	Mus musculus

Alignment Length:	492	Identity:	150/492 - (30%)
Similarity:	232/492 - (47%)	Gaps:	41/492 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 FPPGPPKIPLFGSYLFM----LIINFKYLHKAALTLSRWYKSDIIGLHVGPFPVAVVHSADGVRE 89
            |||||..:|..|:.|.|    |:.:|       :.|...| .|:..:|:||.||.::...|.:||
Mouse    31 FPPGPRPLPFLGNLLQMDRRGLLSSF-------IQLQEKY-GDVFTVHLGPRPVVMLCGTDTIRE 87

  Fly    90 ILNNQ--VFDGRPQLFVAAMRDPGQDVRGIFFQDGPLWKEQRRFILRYLRDFGFGRRFDQLELVI 152
            .|.||  .|.||.   ..|:.||.....|:.|..|..||..|||.|..:||||.|:|  .:|..|
Mouse    88 ALVNQAEAFSGRG---TVAVLDPIVQGYGVIFSSGERWKTLRRFSLATMRDFGMGKR--SVEERI 147

  Fly   153 QEQLNDMLDLIRNGPKYPHEHEMVKSGGYRVLLPLLFNPFSANAHFYIVYNECLSREEMGKLVKL 217
            :|:...:::            |:.|..|..:.....|....||....||:.|....::...|..|
Mouse   148 KEEAQCLVE------------ELKKYKGAPLNPTFYFQCIVANIICSIVFGERFDYKDHQFLHLL 200

  Fly   218 CQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSGYNKLNESNLFVRQFFADFVDKYLDSYEEGVER 282
            ..:...|...:....::..:...|...:|  ..:.:::::...:..:....|:|:..:.:....|
Mouse   201 NLIYQTFSLMSSLSSQVFELFSAILKYFP--GAHRQISKNLQEILDYIGHSVEKHRATLDPSAPR 263

  Fly   283 NFMDVYIAEMRRGPG---YGFNRDQLIMGLVDFSFPA--FTAIGVQLSLLVQYLMLYPAVLRRVQ 342
            :|:|.|:..|.:...   ..|:...|::.::...|..  .|:..::.|.|:  ::.||.|..:||
Mouse   264 DFIDTYLLRMEKEKSNHHTEFHHQNLVISVLSLFFAGTETTSTTLRYSFLI--MLKYPHVAEKVQ 326

  Fly   343 NEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLVPSDVPHKALEDTELLGYRIPKDTIVVP 407
            .|||:|:|..|||.|:||..:|:|:|.|.|..|...|.|..:|||..:||...||.|||:|.|.|
Mouse   327 KEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFTDLAPIGLPHKVTKDTLFRGYLIPKNTEVYP 391

  Fly   408 SLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSLPFGAGKRLCAGETFARNMLFLVTATMC 472
            .|.:...|.|.:..|:.|.||.||||:|.|... :..:||..|||:|.||..|||.|||...|:.
Mouse   392 ILSSALHDPRYFEQPDSFNPEHFLDANGALKTN-EAFMPFSTGKRICLGEGIARNELFLFFTTIL 455

  Fly   473 QHFDFVLGPNDRLPDLSQNLNGLIISPPDFWLQLQDR 509
            |:|...........||..|.:|...:||.:.:....|
Mouse   456 QNFSLASPVAPENIDLIPNNSGATKTPPQYQIHFLSR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	148/484 (31%)
Cyp2b19	NP_031840.1	p450	32..487	CDD:278495	148/484 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910