DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp2a5

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_031838.2	Gene:	Cyp2a5 / 13087	MGIID:	88597	Length:	494	Species:	Mus musculus

Alignment Length:	532	Identity:	147/532 - (27%)
Similarity:	241/532 - (45%)	Gaps:	61/532 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MITETLLTICAAVFLCLSYRYAVGRP---SG-FPPGPPKIPLFGSYLFMLIINFKYLHKAALTLS 61
            |:|..||.:.|..||.:....:|.:.   || .||||..:|..|::   |.:|.:.::.:.:.:|
Mouse     1 MLTSGLLLVAAVAFLSVLVLMSVWKQRKLSGKLPPGPTPLPFIGNF---LQLNTEQMYNSLMKIS 62

  Fly    62 RWYKSDIIGLHVGPFPVAVVHSADGVREILNNQV--FDGRPQ------LFVAAMRDPGQDVRGIF 118
            :.| ..:..:::||..:.|:...:.|:|.|.:|.  |.||.:      ||..         .|:.
Mouse    63 QRY-GPVFTIYLGPRRIVVLCGQEAVKEALVDQAEEFSGRGEQATFDWLFKG---------YGVA 117

  Fly   119 FQDGPLWKEQRRFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHEMVKSGGYRV 183
            |..|...|:.|||.:..|||||.|:|  .:|..|||:...::|..|            |:.|..:
Mouse   118 FSSGERAKQLRRFSIATLRDFGVGKR--GIEERIQEEAGFLIDSFR------------KTNGAFI 168

  Fly   184 LLPLLFNPFSANAHFYIVYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSIIPWI-RHI-WP 246
            ......:...:|....||:.:....|:...|..|..|...||..|...|::..:...: :|: .|
Mouse   169 DPTFYLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSMGQLYEMFSSVMKHLPGP 233

  Fly   247 EWSGYNKLNESNLFVRQFFADFVDKYLDSYEEGVE----RNFMDVYIAEM---RRGPGYGFNRDQ 304
            :...:.:|        |...||:.|.::..:..::    |:|:|.::..|   ::.|...|....
Mouse   234 QQQAFKEL--------QGLEDFITKKVEHNQRTLDPNSPRDFIDSFLIRMLEEKKNPNTEFYMKN 290

  Fly   305 LIMGLVDFSFPAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEAT 369
            |::..::..|.....:...|......||.:|.:..:|..|||.|:|..|.|..|||..:|:|||.
Mouse   291 LVLTTLNLFFAGTETVSTTLRYGFLLLMKHPDIEAKVHEEIDRVIGRNRQPKYEDRMKMPYTEAV 355

  Fly   370 IREGLRIETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDAD 434
            |.|..|...::|..:..:..:||:...:.:||.|.|.|.|.:...|.:.:|:|:.|.|:.|||..
Mouse   356 IHEIQRFADMIPMGLARRVTKDTKFRDFLLPKGTEVFPMLGSVLKDPKFFSNPKDFNPKHFLDDK 420

  Fly   435 GKLCLKLDVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDF--VLGPNDRLPDLSQNLNGLII 497
            |:. .|.|..:||..|||.|.||..||..|||....:.|:|.|  ...|.|  .|:|..|.|...
Mouse   421 GQF-KKNDAFVPFSIGKRYCFGEGLARMELFLFLTNIMQNFHFKSTQAPQD--IDVSPRLVGFAT 482

  Fly   498 SPPDFWLQLQDR 509
            .||.:.:....|
Mouse   483 IPPTYTMSFLSR 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	136/492 (28%)
Cyp2a5	NP_031838.2	p450	34..491	CDD:278495	136/494 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910