DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp304a1 and Cyp2a4

DIOPT Version :9

Sequence 1:NP_731751.1 Gene:Cyp304a1 / 41586 FlyBaseID:FBgn0038095 Length:510 Species:Drosophila melanogaster
Sequence 2:NP_034127.2 Gene:Cyp2a4 / 13086 MGIID:88596 Length:494 Species:Mus musculus


Alignment Length:530 Identity:146/530 - (27%)
Similarity:239/530 - (45%) Gaps:57/530 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MITETLLTICAAVFLCLSYRYAVGRP---SG-FPPGPPKIPLFGSYLFMLIINFKYLHKAALTLS 61
            |:|..||.:.|..||.:....:|.:.   || .||||..:|..|::   |.:|.:.::.:.:.:|
Mouse     1 MLTSGLLLVAAVAFLSVLVLMSVWKQRKLSGKLPPGPTPLPFVGNF---LQLNTEQMYNSLMKIS 62

  Fly    62 RWYKSDIIGLHVGPFPVAVVHSADGVREILNNQV--FDGRPQ------LFVAAMRDPGQDVRGIF 118
            :.| ..:..:::|...:.|:...:.|:|.|.:|.  |.||.:      ||..         .||.
Mouse    63 QRY-GPVFTIYLGSRRIVVLCGQETVKEALVDQAEEFSGRGEQATFDWLFKG---------YGIA 117

  Fly   119 FQDGPLWKEQRRFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHEMVKSGGYRV 183
            |..|...|:.|||.:..|||||.|:|  .:|..|||:...::|..|            |:.|..:
Mouse   118 FSSGERAKQLRRFSITTLRDFGVGKR--GIEERIQEEAGFLIDSFR------------KTNGAFI 168

  Fly   184 LLPLLFNPFSANAHFYIVYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSIIPWI-RHI-WP 246
            ......:...:|....||:.:....|:...|..|..|....|..|...|::..:...: :|: .|
Mouse   169 DPTFYLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSLQFTATSMGQVYEMFSSVMKHLPGP 233

  Fly   247 EWSGYNKLNESNLFVRQFFADFVDKYLDSYEEGVE----RNFMDVYIAEM---RRGPGYGFNRDQ 304
            :...:.:|        |...||:.|.::..:..::    |:|:|.::..|   ::.|...|....
Mouse   234 QQQAFKEL--------QGLEDFITKKVEHNQRTLDPNSPRDFIDSFLIRMLEEKKNPNTEFYMKN 290

  Fly   305 LIMGLVDFSFPAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEAT 369
            |::..::..|.....:...|......||.||.:..:|..|||.|:|..|.|..|||..:|:|||.
Mouse   291 LVLTTLNLFFAGTETVSTTLRYGFLLLMKYPDIEAKVHEEIDRVIGRNRQPKYEDRMKMPYTEAV 355

  Fly   370 IREGLRIETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDAD 434
            |.|..|...|:|..:..:..:||:...:.:||.|.|.|.|.:...|.:.:|:|:.|.|:.|||..
Mouse   356 IHEIQRFADLIPMGLARRVTKDTKFRDFLLPKGTEVFPMLGSVLKDPKFFSNPKDFNPKHFLDDK 420

  Fly   435 GKLCLKLDVSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDFVLGPNDRLPDLSQNLNGLIISP 499
            |:. .|.|..:||..|||.|.||..||..|||....:.|:|.|......:..|:|..|.|.:..|
Mouse   421 GQF-KKSDAFVPFSIGKRYCFGEGLARMELFLFLTNIMQNFHFKSTQEPQDIDVSPRLVGFVTIP 484

  Fly   500 PDFWLQLQDR 509
            |.:.:....|
Mouse   485 PTYTMSFLSR 494

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp304a1NP_731751.1 p450 30..504 CDD:278495 135/490 (28%)
Cyp2a4NP_034127.2 p450 34..491 CDD:278495 135/492 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X6
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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