DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp304a1 and Cyp1a1

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001129531.1	Gene:	Cyp1a1 / 13076	MGIID:	88588	Length:	524	Species:	Mus musculus

Alignment Length:	516	Identity:	143/516 - (27%)
Similarity:	229/516 - (44%)	Gaps:	70/516 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TETLLTI---CAAVFLCLSYRYAVGRPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWY 64
            ||.||.:   |...::..:.|..|.:....||||..:|..|   .||.:. |..|.:...||:.|
Mouse    14 TELLLAVTVFCLGFWVVRATRTWVPKGLKTPPGPWGLPFIG---HMLTVG-KNPHLSLTRLSQQY 74

  Fly    65 KSDIIGLHVGPFPVAVVHSADGVREILNNQ--VFDGRPQLFVAAMRDPGQDVRGIFFQD-GPLWK 126
             .|::.:.:|..||.|:...:.:::.|..|  .|.|||.|:...:...|:.:  .|..| ||:|.
Mouse    75 -GDVLQIRIGSTPVVVLSGLNTIKQALVRQGDDFKGRPDLYSFTLITNGKSM--TFNPDSGPVWA 136

  Fly   127 EQRRFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPK-----YPHEHEMVKSGGYRV--L 184
            .:||.....|:.|.                      |.:.|.     |..|| :.|...|.|  |
Mouse   137 ARRRLAQNALKSFS----------------------IASDPTSASSCYLEEH-VSKEANYLVSKL 178

  Fly   185 LPLL-----FNPFS------ANAHFYIVYNECLSREEMGKLVKLCQMGIQFQRNADDYGKMLSII 238
            ..::     |:|:.      ||....|.:.:....::. :|:.:..:..:| ......|.....|
Mouse   179 QKVMAEVGHFDPYKYLVVSVANVICAICFGQRYDHDDQ-ELLSIVNLSNEF-GEVTGSGYPADFI 241

  Fly   239 PWIRHIWPEWS--GYNKLNESNLFVRQFFADFVDKYLDSYEEGVERNFMDVYI-----AEMRRGP 296
            |.:|:: |..|  .:..||:.   ...|....:.::..::|:|..|:..|..|     .::....
Mouse   242 PVLRYL-PNSSLDAFKDLNDK---FYSFMKKLIKEHYRTFEKGHIRDITDSLIEHCQDRKLDENA 302

  Fly   297 GYGFNRDQLIMGLVDFSFPAFTAIGVQLSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRK 361
            ....:.|::|..::|.....|..:...:|..:.||:..|.|.|::|.|:|.|:|..|.|.|.||.
Mouse   303 NVQLSDDKVITIVLDLFGAGFDTVTTAISWSLMYLVTNPRVQRKIQEELDTVIGRDRQPRLSDRP 367

  Fly   362 NLPFTEATIREGLRIETLVPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFR 426
            .||:.||.|.|..|..:.||..:||....||.|.|:.|||...|..:.:..:.|..:|.||.:||
Mouse   368 QLPYLEAFILETFRHSSFVPFTIPHSTTRDTSLNGFYIPKGCCVFVNQWQVNHDRELWGDPNEFR 432

  Fly   427 PERFLDADGKLCLKLD--VSLPFGAGKRLCAGETFARNMLFLVTATMCQHFDFVLGPNDRL 485
            |||||...|.|..:|.  |:| ||.|||.|.|||..|:.:||..|.:.|..:|.:.|.:::
Mouse   433 PERFLTPSGTLDKRLSEKVTL-FGLGKRKCIGETIGRSEVFLFLAILLQQIEFKVSPGEKV 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	136/486 (28%)
Cyp1a1	NP_001129531.1	Mitochondrial targeting signal. /evidence=ECO:0000250\|UniProtKB:P00185	33..44		2/10 (20%)
Cyp1a1	NP_001129531.1	p450	44..503	CDD:365848	136/486 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910