Protein Alignment Cyp304a1 and CYP2R1

DIOPT Version :9

• Sequence 1: NP_731751.1
• Gene: Cyp304a1 / 41586
• FlyBaseID: FBgn0038095
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_078790.2
• Gene: CYP2R1 / 120227
• HGNCID: 20580
• Length: 501
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 149/520 - (28%)
• Similarity: 246/520 - (47%)
• Gaps: 57/520 - (10%)

  Fly    12 AVFLCLSYRYAVG--------RPSGFPPGPPKIPLFGSYLFMLIINFKYLHKAALTLSRWYKSDI 68
            |:||.|   :|:|        ||.|||||||.:|..|: ::.|..:.:..|......|:.| .:|
Human    17 ALFLLL---FALGVRQLLKQRRPMGFPPGPPGLPFIGN-IYSLAASSELPHVYMRKQSQVY-GEI 76

  Fly    69 IGLHVGPFPVAVVHSADGVREIL--NNQVFDGRP--QLFVAAMRDPGQDVRGIFFQDGPLWKEQR 129
            ..|.:|.....|::..|.|:|.|  .:::|..||  .||:...:..|.    :..:.|..|.:.|
Human    77 FSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGL----LNSRYGRGWVDHR 137

  Fly   130 RFILRYLRDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHEMVKSGGYRVLLPLLFNPFSA 194
            |..:...|.||:|::  ..|..|.|:.....|.|......|.:.:.           |:.|..|
Human   138 RLAVNSFRYFGYGQK--SFESKILEETKFFNDAIETYKGRPFDFKQ-----------LITNAVS- 188

  Fly   195 NAHFYIVYNECLSRE--EMGKLVKLCQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSGYNKLNES 257
            |....|::.|..:.|  :...:::|....::...:|..:  :.:..||| .|.| :..:.:|..:
Human   189 NITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVF--LYNAFPWI-GILP-FGKHQQLFRN 249

  Fly   258 NLFVRQFFADFVDKYLDSYEEGVERNFMDVYIAEMRRG---PGYGFNRDQLIMGLVDFSFPAFTA 319
            ...|..|.:..::|...:.:..:.::|:|.|:.||.:|   |...|:::.||     ||......
Human   250 AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLI-----FSVGELII 309

  Fly   320 IGVQ-----LSLLVQYLMLYPAVLRRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETL 379
            .|.:     |...:.::.|||.:..:||.|||.::|....|:.:|:..:|:|||.:.|.||...:
Human   310 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNI 374

  Fly   380 VPSDVPHKALEDTELLGYRIPKDTIVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVS 444
            ||..:.|...||..:.||.|||.|.|:.:||:.|.|.:.|.|||.|.||||||:.|... |.:..
Human   375 VPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFA-KKEAL 438

  Fly   445 LPFGAGKRLCAGETFARNMLFLVTATMCQHFDFVLGPNDRLPDLSQNLNGLIISPPDFWLQLQDR 509
            :||..|:|.|.||..||..:||....:.|.|.... |::.:|||...| |:.:.|..:.:..:.|
Human   439 VPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHF-PHELVPDLKPRL-GMTLQPQPYLICAERR 501

  Fly   510  509
            Human   502  501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	138/487 (28%)
CYP2R1	NP_078790.2	p450	57..497	CDD:278495	130/470 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910