DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp304a1 and CYP2U1

DIOPT Version :9

Sequence 1:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_005262774.1	Gene:	CYP2U1 / 113612	HGNCID:	20582	Length:	562	Species:	Homo sapiens

Alignment Length:	561	Identity:	167/561 - (29%)
Similarity:	258/561 - (45%)	Gaps:	93/561 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LTICAAVFLC----LSYRYAVGRPSGFPPGPPKIPLFGSYLFMLIINF----KYLH---KAA--- 57
            |.:|..|.|.    |..|    |..|.||||...||.|::..:|:..|    .:|.   :||
Human    37 LLLCGLVALLGWSWLRRR----RARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGID 97

  Fly    58 ----------LTLSRWYKSDIIGLHVGPFPVAVVHSADGVREILNNQ--VFDGRPQ--LFVAAMR 108
                      ..|:|.|.| |....:|.:.|.|:.....|||.|..|  ||..||:  |.....:
Human    98 PSVIGPQVLLAHLARVYGS-IFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTK 161

  Fly   109 DPGQ-DVRG-------------IFFQDGPLWKEQRRFILRYLRDFGFGRRFDQLELVIQEQLNDM 159
            :.|: :|.|             :|...||:|::||:|....||.||.|:.  .||..|.|:.
Human   162 EKGEREVVGCGYADAADESPGVVFAHYGPVWRQQRKFSHSTLRHFGLGKL--SLEPKIIEEF--- 221

  Fly   160 LDLIRNGPKYPHEHEMVKSGGYRVLLPLLFNPFS--ANAHFYIVYNECL------SREEMGKLVK 216
                    ||. :.||.|.|...      |.|||  :||...|:.:.|.      :..|..|::.
Human   222 --------KYV-KAEMQKHGEDP------FCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLG 271

  Fly   217 LCQMGIQFQRNADDYGKMLSIIPWIRHIWPEWSGYNKLNESNLFVRQFFADFVDKYLDSYEEGVE 281
            ....|::...|:...  :::|.||:.::  .:..:.:|.:    :.:....|:.|.:..::|.::
Human   272 FMSRGLEICLNSQVL--LVNICPWLYYL--PFGPFKELRQ----IEKDITSFLKKIIKDHQESLD 328

  Fly   282 R----NFMDVYIAEM----RRGPGYGFNRDQLIMGLVDFSFPAFTAIGVQLSLLVQYLMLYPAVL 338
            |    :|:|:|:..|    :......|:.:.|...:.|............|...:.|:.|.|.|.
Human   329 RENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQ 393

  Fly   339 RRVQNEIDEVVGCGRLPNLEDRKNLPFTEATIREGLRIETLVPSDVPHKALEDTELLGYRIPKDT 403
            .:|..||:.|:|..|.|:|.|:..:|:|||||.|..|:..:||..:||...|:|.|.||.|||.|
Human   394 EKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGT 458

  Fly   404 IVVPSLYAFHSDARIWSDPEQFRPERFLDADGKLCLKLDVSLPFGAGKRLCAGETFARNMLFLVT 468
            :::|:|::.|.|..||..||.|.|.||||..|:| :|.:..:|||.|||:|.||..|:..|||:.
Human   459 LILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQL-IKKETFIPFGIGKRVCMGEQLAKMELFLMF 522

  Fly   469 ATMCQHFDFVLGPNDRLPDLSQNLNGLIISPPDFWLQLQDR 509
            .::.|.|.|.| |.|....|.....||.::|..|.:.:..|
Human   523 VSLMQSFAFAL-PEDSKKPLLTGRFGLTLAPHPFNITISRR 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	158/527 (30%)
CYP2U1	XP_005262774.1	p450	60..555	CDD:278495	157/525 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910