DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10909 and pclob

DIOPT Version :9

Sequence 1:	NP_650236.1	Gene:	CG10909 / 41581	FlyBaseID:	FBgn0038090	Length:	349	Species:	Drosophila melanogaster
Sequence 2:	XP_009291733.1	Gene:	pclob / 565842	ZFINID:	ZDB-GENE-030131-8100	Length:	9355	Species:	Danio rerio

Alignment Length:	305	Identity:	68/305 - (22%)
Similarity:	106/305 - (34%)	Gaps:	83/305 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RSPPSSTLEEEVPG-KTIHPEDPKITSKNFENP-----TKETSIQSPIKNSIKPS---------- 58
            :|.|:||..:|..| ..:.|..|.....|.|.|     .|||..::|...|...|
Zfish  2545 QSKPTSTPTQEQKGPPDVQPSKPLEAELNKEPPKSCPLCKETLKKTPQNYSSCTSCKSIVCNLCG 2609

  Fly    59 WNPEPKITRTSIW-----DIESAGGDSI-QNDCQSECNVEDQGHEQEVTLETRIF-------SGT 110
            :||.|..|....|     .:....|..: |.:.||...:......:|   :|::.       |.|
Zfish  2610 FNPNPHQTDVKEWLCLTCQMHKTSGPPLPQPEPQSNIALAPASPLKE---KTQVSPSPEKKPSVT 2671

  Fly   111 SDRIEPHRHYGVYLLRNRFDAIQLLTRNTSSSADDYGERRVI-----SEYREMRCEF-------R 163
            :|:.:          :...:..:|.|.||..|..|....:.:     .:.:|....|       |
Zfish  2672 ADQDK----------KPLAETKELKTPNTQKSKGDVPSSKPVPPPKGEQVKEESSFFGFGFGSSR 2726

  Fly   164 VWSPFQSKLAAGIMGGVSDLHLQIGSKVLYLGAGFGRSVSH-ISDIVGDSGMVYAVEQIPWAGRQ 227
            ..||..|..||     |||       ||...|:.|..|.|: ||..|.|..   :.:..|.:.:.
Zfish  2727 SRSPSPSPQAA-----VSD-------KVFGFGSSFLSSASNLISSAVQDES---STKTPPTSRKG 2776

  Fly   228 LTIM-----------ANRRSNIVPIVEDATMPYKYRYEVPACIDI 261
            .|:.           .:|:.:::|  :||......|...||...|
Zfish  2777 STVSQVSNKTTPTPPTSRKGSVIP--QDAKQKQPQRESKPAVSSI 2819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10909	NP_650236.1	Fibrillarin	114..344	CDD:279593	37/172 (22%)
pclob	XP_009291733.1	DNA_pol3_gamma3	<35..208	CDD:331207
		zf-piccolo	218..275	CDD:310374
		zf-piccolo	512..567	CDD:310374
		zf-piccolo	798..853	CDD:310374
		zf-piccolo	1068..1122	CDD:310374
		zf-piccolo	1336..1390	CDD:310374
		zf-piccolo	1609..1660	CDD:310374
		Herpes_ICP4_C	1746..>2029	CDD:332854
		zf-piccolo	2057..2111	CDD:310374
		zf-piccolo	2315..2369	CDD:310374
		DUF4045	<2372..2688	CDD:330572	32/155 (21%)
		zf-piccolo	2578..2629	CDD:310374	11/50 (22%)
		zf-piccolo	2845..2899	CDD:310374
		TOP2c	<2885..3106	CDD:330395
		zf-piccolo	3106..3160	CDD:310374
		zf-piccolo	3399..3457	CDD:310374
		Atrophin-1	<3483..4034	CDD:331285
		zf-piccolo	3729..3786	CDD:310374
		zf-piccolo	4063..4120	CDD:310374
		zf-piccolo	4395..4452	CDD:310374
		Atrophin-1	<4460..5042	CDD:331285
		zf-piccolo	4732..4789	CDD:310374
		zf-piccolo	5090..5147	CDD:310374
		RNase_E_G	<5155..5304	CDD:331378
		Neuromodulin_N	<5320..>5731	CDD:331332
		Atrophin-1	<6000..6417	CDD:331285
		ERM	<7511..>7597	CDD:330563
		PDZ_signaling	8690..8781	CDD:238492
		C2A_RIM1alpha	8887..9021	CDD:175997
		C2	9236..9346	CDD:326325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910