DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10126 and DCLK3

DIOPT Version :9

Sequence 1:	NP_788664.2	Gene:	CG10126 / 41579	FlyBaseID:	FBgn0038088	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_001381601.1	Gene:	DCLK3 / 85443	HGNCID:	19005	Length:	817	Species:	Homo sapiens

Alignment Length:	195	Identity:	42/195 - (21%)
Similarity:	74/195 - (37%)	Gaps:	57/195 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LREI--------RTK--GWSLKNPNCDLYTLEANMASQALRELTDGEDKDPITKLRLLCLSRGAT 57
            |||:        |:|  ||.|:         |.....:.||. |.||:|: ..|.:..|:|.
Human   426 LREVKKDTRPMSRSKHGGWLLR---------EHQAGFEKLRR-TRGEEKE-AEKEKKPCMSG--- 476

  Fly    58 GILGLGRAFRAMDDDGSK---------ALNEEEFITGIRDTGLDVSEEEIKQMFATFDEDGSGSI 113
                 ||.....||..:|         ..|:.|..:|.:...:.:....:::.:.|....|.|:.
Human   477 -----GRRMTLRDDQPAKLEKEPKTRPEENKPERPSGRKPRPMGIIAANVEKHYETGRVIGDGNF 536

  Fly   114 NMTE----------FLLKLRPPMPQSRLNIIDQAFNKMDRDEDGVITIQDLKNVYSVKEHPKYQS 168
            .:.:          :.:|:   :.:|||.      .|.|..:..::.||.|.:...||.|..|::
Human   537 AVVKECRHRETRQAYAMKI---IDKSRLK------GKEDMVDSEILIIQSLSHPNIVKLHEVYET 592

Fly 169 168
Human 593 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10126	NP_788664.2	EF-hand_7	62..119	CDD:290234	11/75 (15%)
		EFh	64..119	CDD:238008	10/73 (14%)
		EFh	97..154	CDD:238008	11/66 (17%)
		EF-hand_7	98..158	CDD:290234	12/69 (17%)
		EF-hand_7	134..204	CDD:290234	9/35 (26%)
DCLK3	NP_001381601.1	DCX_DCLK3	93..177	CDD:340528
DCLK3	NP_001381601.1	STKc_DCKL3	524..781	CDD:271087	16/78 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900