DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10126 and CAPS

DIOPT Version :9

Sequence 1:	NP_788664.2	Gene:	CG10126 / 41579	FlyBaseID:	FBgn0038088	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_004049.3	Gene:	CAPS / 828	HGNCID:	1487	Length:	189	Species:	Homo sapiens

Alignment Length:	180	Identity:	85/180 - (47%)
Similarity:	121/180 - (67%)	Gaps:	2/180 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KLRLLCLSRGATGILGLGRAFRAMDDDGSKALNEEEFITGIRDTGLDVSEEEIKQMFATFDEDGS 110
            |||..||||||:||.||.|.||.:|.|||::|:.:||..|:...||.:.:.|.:.:...:|.:||
Human    10 KLRAQCLSRGASGIQGLARFFRQLDRDGSRSLDADEFRQGLAKLGLVLDQAEAEGVCRKWDRNGS 74

  Fly   111 GSINMTEFLLKLRPPMPQSRLNIIDQAFNKMDRDEDGVITIQDLKNVYSVKEHPKYQSGEKSEDE 175
            |::::.|||..|||||.|:|..:|..||.|:||..|||:|:.||:.|||.:.|||.:|||.:|||
Human    75 GTLDLEEFLRALRPPMSQAREAVIAAAFAKLDRSGDGVVTVDDLRGVYSGRAHPKVRSGEWTEDE 139

  Fly   176 ILTDFLHNFEGGRGNLDGKITREEFVNYYATISASIDNDMFFDLMMRRAY 225
            :|..||.||:.  ...||::|..||.:||:.:|||::.|..|..||..|:
Human   140 VLRRFLDNFDS--SEKDGQVTLAEFQDYYSGVSASMNTDEEFVAMMTSAW 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10126	NP_788664.2	EF-hand_7	62..119	CDD:290234	20/56 (36%)
		EFh	64..119	CDD:238008	19/54 (35%)
		EFh	97..154	CDD:238008	25/56 (45%)
		EF-hand_7	98..158	CDD:290234	26/59 (44%)
		EF-hand_7	134..204	CDD:290234	34/69 (49%)
CAPS	NP_004049.3	EFh_PI-PLC	26..165	CDD:333715	63/140 (45%)
		EFh	26..87	CDD:238008	22/60 (37%)
		EF-hand motif	26..54	CDD:320029	12/27 (44%)
		EF-hand motif	61..89	CDD:320029	10/27 (37%)
		EF-hand motif	94..131	CDD:320029	19/36 (53%)
		EF-hand motif	139..165	CDD:320029	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I8408
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56894
OrthoDB	1	1.010	-	-		D1377102at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8486
orthoMCL	1	0.900	-	-		OOG6_103375
Panther	1	1.100	-	-	O	PTHR34524
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.930