DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10126 and TRIO

DIOPT Version :9

Sequence 1:	NP_788664.2	Gene:	CG10126 / 41579	FlyBaseID:	FBgn0038088	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_009049.2	Gene:	TRIO / 7204	HGNCID:	12303	Length:	3097	Species:	Homo sapiens

Alignment Length:	254	Identity:	54/254 - (21%)
Similarity:	83/254 - (32%)	Gaps:	89/254 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FLREIRTKGWSLKNPNCDLYTLEANMASQALRELTDGEDKDPITKLRLLCLSRGATGILGLGRAF 66
            |.::.||...|.|      :..|.||.|  |..||...|...:|.
Human   164 FWQKQRTNFGSSK------FEFETNMVS--LEGLTKVVDPSQLTP-------------------- 200

  Fly    67 RAMDDDGSKALNEEEFITGIRDTGLD-VSE--------EEIKQMFA--TFDEDGSGSINMTEFLL 120
               :.||....|.||:|. ||....| :|.        ||::.:.|  ...:|..|:.||.|...
Human   201 ---EFDGCLEYNHEEWIE-IRVAFEDYISNATHMLSRLEELQDILAKKELPQDLEGARNMIEEHS 261

  Fly   121 KLRPPMPQSRLNIIDQAFNKMDRDEDGVITIQDLKNVYSVKEHPKYQSGEKSED--------EIL 177
            :|:..:.::.:..:|....|:            |:.:.|.:..||..||..:.|        ..:
Human   262 QLKKKVIKAPIEDLDLEGQKL------------LQRIQSSESFPKKNSGSGNADLQNLLPKVSTM 314

  Fly   178 TDFLHN------------------------FEGGRGNLDGKITREE--FVNYYATISAS 210
            .|.||:                        ||.....:...||..:  |:|.|..|..|
Human   315 LDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNKGLFLNSYTEIGTS 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10126	NP_788664.2	EF-hand_7	62..119	CDD:290234	18/67 (27%)
		EFh	64..119	CDD:238008	18/65 (28%)
		EFh	97..154	CDD:238008	10/58 (17%)
		EF-hand_7	98..158	CDD:290234	10/61 (16%)
		EF-hand_7	134..204	CDD:290234	18/103 (17%)
TRIO	NP_009049.2	SEC14	69..204	CDD:214706	14/70 (20%)
		SPEC	230..445	CDD:238103	30/156 (19%)
		Spectrin 1	311..418		12/63 (19%)
		SPEC	341..566	CDD:238103	9/33 (27%)
		Spectrin 2	538..644
		SPEC	567..783	CDD:238103
		SPEC	787..1014	CDD:238103
		Spectrin 3	878..984
		SPEC	908..1137	CDD:238103
		Spectrin 4	1109..1216
		SPEC	1143..1243	CDD:197544
		RhoGEF	1295..1465	CDD:238091
		PH1_Kalirin_Trio_like	1472..1594	CDD:270060
		PH	1505..1590	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1601..1650
		SH3_Kalirin_1	1659..1718	CDD:212786
		SH3-RhoG_link	1715..1972	CDD:293215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1779..1906
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1927..1965
		RhoGEF	1970..2143	CDD:238091
		PH2_Kalirin_Trio_p63RhoGEF	2148..2286	CDD:270061
		PH	2175..2271	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2287..2552
		SH3_Kalirin_2	2555..2613	CDD:212787
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2639..2660
		I-set	2685..2776	CDD:254352
		Ig	2699..2776	CDD:299845
		STKc_Trio_C	2788..3050	CDD:271015
		S_TKc	2796..3050	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900