DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10126 and STK33

DIOPT Version :9

Sequence 1:	NP_788664.2	Gene:	CG10126 / 41579	FlyBaseID:	FBgn0038088	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_001275990.1	Gene:	STK33 / 65975	HGNCID:	14568	Length:	514	Species:	Homo sapiens

Alignment Length:	193	Identity:	40/193 - (20%)
Similarity:	75/193 - (38%)	Gaps:	52/193 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SLKNPNCDLYTLEANMASQALRELTDGEDKDPI----TKLR---LLCLSRGATGILGLGRAFRAM 69
            |.|.|:|       :.|||          ||.:    :|.|   :|.:....|..:|...:..::
Human    10 STKCPDC-------SSASQ----------KDVLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISL 57

  Fly    70 DDDGSKALNEEEFITGIRDTGLDVSEEEIKQMFATFDEDGSGSINMTEFLLKLRPPMPQSRLN-- 132
            :....|.:|.:  ||..:|.....|..|.|   |:..:.|.|  |.||      ..:|..|:.
Human    58 ERKKEKNINRD--ITSRKDLPSRTSNVERK---ASQQQWGRG--NFTE------GKVPHIRIENG 109

  Fly   133 -IIDQAF---NKMDRDEDGVI---TIQDLKNVYSVKEHPKYQSGEKS------EDEILTDFLH 182
             .|::.:   ..:.:...|::   |.::.:..:::|:..|.::|..:      |..||....|
Human   110 AAIEEIYTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKH 172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10126	NP_788664.2	EF-hand_7	62..119	CDD:290234	14/56 (25%)
		EFh	64..119	CDD:238008	14/54 (26%)
		EFh	97..154	CDD:238008	13/65 (20%)
		EF-hand_7	98..158	CDD:290234	12/68 (18%)
		EF-hand_7	134..204	CDD:290234	10/61 (16%)
STK33	NP_001275990.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..91		8/30 (27%)
		STKc_STK33	114..381	CDD:270999	9/59 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..468
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..514
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900