DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10126 and Trio

DIOPT Version :9

Sequence 1:	NP_788664.2	Gene:	CG10126 / 41579	FlyBaseID:	FBgn0038088	Length:	227	Species:	Drosophila melanogaster
Sequence 2:	NP_001074771.1	Gene:	Trio / 223435	MGIID:	1927230	Length:	3103	Species:	Mus musculus

Alignment Length:	260	Identity:	56/260 - (21%)
Similarity:	81/260 - (31%)	Gaps:	101/260 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FLREIRTKGWSLKNPNCDLYTLEANMASQALRELTDGEDKDPITKLRLLCLSRGATGILGLGRAF 66
            |.::.||...|.|      :..|.||.|  |..||...|...:|.
Mouse   164 FWQKQRTNFGSSK------FEFETNMVS--LEGLTKVVDPSQLTP-------------------- 200

  Fly    67 RAMDDDGSKALNEEEFITGIRDTGLDVSEEEIKQMFATFDEDGSGSINMTEFLLKLRPPMPQSRL 131
               :.||....|.||:|             ||:   ..|:|..|.:.:|...|.:|:..:.:..|
Mouse   201 ---EFDGCLEYNHEEWI-------------EIR---VAFEEYISNAAHMLSRLEELQDVLAKKEL 246

  Fly   132 --------NIID---QAFNKM------DRDEDGVITIQDLKNVYSVKEHPKYQSGEKSED----- 174
                    |:||   |...|:      |.|.:|...:|   .:.|....||..||..:.|
Mouse   247 PQDLEGARNMIDEHSQLKKKVIKAPIEDLDLEGQKLLQ---RIQSSDSFPKKNSGSGNADLQNLL 308

  Fly   175 ---EILTDFLHN------------------------FEGGRGNLDGKITREE--FVNYYATISAS 210
               ..:.|.||:                        ||.....:...||..:  |:|.|..|..|
Mouse   309 PKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNKGLFLNSYTEIGTS 373

Fly 211 210
Mouse 374 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10126	NP_788664.2	EF-hand_7	62..119	CDD:290234	12/56 (21%)
		EFh	64..119	CDD:238008	12/54 (22%)
		EFh	97..154	CDD:238008	18/73 (25%)
		EF-hand_7	98..158	CDD:290234	17/76 (22%)
		EF-hand_7	134..204	CDD:290234	23/112 (21%)
Trio	NP_001074771.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		SEC14	69..204	CDD:214706	14/70 (20%)
		Spectrin 1	218..338		25/122 (20%)
		SPEC	220..445	CDD:238103	34/157 (22%)
		Spectrin 2	340..446		9/34 (26%)
		SPEC	341..566	CDD:238103	9/33 (27%)
		Spectrin 3	566..672
		SPEC	567..783	CDD:238103
		Spectrin 4	673..784
		SPEC	787..1014	CDD:238103
		Spectrin 5	907..1012
		SPEC	908..1137	CDD:238103
		Spectrin 6	1138..1244
		SPEC	1143..1243	CDD:197544
		RhoGEF	1295..1465	CDD:238091
		PH1_Kalirin_Trio_like	1472..1594	CDD:270060
		PH	1505..1590	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1601..1651
		SH3_Kalirin_1	1659..1718	CDD:212786
		SH3-RhoG_link	1715..1972	CDD:293215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1781..1906
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1927..1957
		RhoGEF	1970..2143	CDD:238091
		PH2_Kalirin_Trio_p63RhoGEF	2148..2286	CDD:270061
		PH	2175..2271	CDD:278594
		SH3_Kalirin_2	2559..2617	CDD:212787
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2643..2666
		I-set	2689..2780	CDD:254352
		Ig	2703..2780	CDD:299845
		STKc_Trio_C	2792..3054	CDD:271015
		S_TKc	2800..3054	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900