Protein Alignment Ugt37A3 and UGT2A3

DIOPT Version :10

• Sequence 1: NP_650229.2
• Gene: Ugt37A3 / 41574
• FlyBaseID: FBgn0038083
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: XP_011530549.1
• Gene: UGT2A3 / 79799
• HGNCID: 28528
• Length: 533
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 123/524 - (23%)
• Similarity: 238/524 - (45%)
• Gaps: 74/524 - (14%)

  Fly    47 KVLAE----NGHNVTVVTVLKP-VVNHK-----NITVIQVPLSKEEAQQMSDTIGAMSKNDNSNM 101
            ||:.|    .||.|||:|..|| :::::     ...|:.:|..:.|..::.           .::
Human    40 KVILEELIVRGHEVTVLTHSKPSLIDYRKPSALKFEVVHMPQDRTEENEIF-----------VDL 93

  Fly   102 ALSLLRMSDQMDFMIRKNAETLMNDRVRDLYLNRGNKFDLVISGYFMNDFQLGFARKVNAPVIVL 166
            ||::|........:|:.|          |.::.......::...:..|...:...::.|..|:::
Human    94 ALNVLPGLSTWQSVIKLN----------DFFVEIRGTLKMMCESFIYNQTLMKKLQETNYDVMLI 148

  Fly   167 -ATMPPNHLLNPLIGNP----LEVSYAG---------------ISNPAEG-SKAVTFQRRLSSYM 210
             ..:|...|:..|:..|    |.:|..|               :..|..| :..:||..|:.:.|
Human   149 DPVIPCGDLMAELLAVPFVLTLRISVGGNMERSCGKLPAPLSYVPVPMTGLTDRMTFLERVKNSM 213

  Fly   211 QSLGFGVFSHLSERRNRNWYKEVYGNDPKMP-EYSEMLKNTSLVFFSSHAASEGPIRPNVPSAIE 274
            .|:   :|....:..:.::::|.|......| ...|.:....:....::...|.| :|..|:...
Human   214 LSV---LFHFWIQDYDYHFWEEFYSKALGRPTTLCETVGKAEIWLIRTYWDFEFP-QPYQPNFEF 274

  Fly   275 IGGIQIKDKPDPLP------QNIAEFL-GNATDGAILLSLGSNVQGKHLNPDTVAKMFNVLSKLK 332
            :||:..| ....||      |.:..|: .:..||.::.||||..|  ::..:....:.:.|:::.
Human   275 VGGLHCK-PAKALPKINFYLQEMENFVQSSGEDGIVVFSLGSLFQ--NVTEEKANIIASALAQIP 336

  Fly   333 ERVIWKWEDQE-NTPGKSANILYSKWLPQDDILAHPNIKLFINHAGKGGITESQYHGKPMLSLPV 396
            ::|:|:::.:: :|.|  ||.....|:||:|:|.||..|.||.|.|..||.|:.|||.||:.:|:
Human   337 QKVLWRYKGKKPSTLG--ANTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPI 399

  Fly   397 FADQPRNANAMVKSGFGLTLSLLTLEEKPFQEAILEILSNPQYAERVKSFSTLYRDRPMTARESF 461
            |.||..|...|...|..:.::..|:..:....|:..::::..|.|.....|.::.|:|:...:..
Human   400 FGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRA 464

  Fly   462 LYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIC-FLIFVILVSVLVLIK-FLVQFIYRRFISKP 524
            ::|.|:|:||.||.||:|....:::....:||:. ||:..:..::.:..| ||  |..::|....
Human   465 VFWIEFVMRHKGAKHLRSAAHDLTWFQHYSIDVIGFLLACVATAIFLFTKCFL--FSCQKFNKTR 527

  Fly   525 KKEK 528
            |.||
Human   528 KIEK 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A3	NP_650229.2	GT1_Gtf-like	25..464	CDD:340817	101/456 (22%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	120/519 (23%)